Can I take Co-codamol and Sertraline together?

Why this happens

Both drugs affect a chemical in the brain called serotonin; when levels get too high, it causes side effects. Furthermore, sertraline blocks a specific liver enzyme (CYP2D6) that the body needs to convert codeine into morphine. If this conversion doesn't happen, the pain-killing effect is lost.

What you should do

Speak to your doctor before combining these medicines. If you must take both, be alert for signs of serotonin syndrome, such as shivering, diarrhoea, fever, sweating, or muscle stiffness. If you find that co-codamol is not helping your pain, your doctor may suggest an alternative painkiller like paracetamol (without codeine) or ibuprofen.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.