Can I take Colecalciferol and Prednisolone together?

Why this happens

Prednisolone is a steroid medication that interferes with how your body processes vitamin D. It can speed up the breakdown of vitamin D and also reduce how much calcium your body absorbs from your food, which vitamin D normally helps with.

You can take these medicines together, but your doctor may need to monitor your vitamin D and calcium levels with blood tests. In some cases, a higher dose of colecalciferol or an additional calcium supplement may be recommended to protect your bone health while you are taking steroids.

Hypercalcaemia (high blood calcium)

Do not take colecalciferol if you have high levels of calcium in your blood or urine, or if you have severe kidney stones, as vitamin D increases calcium absorption and can worsen these conditions.

Infection exposure (Chickenpox, Shingles, Measles)

You must avoid contact with anyone who has chickenpox, shingles, or measles. If you are exposed, contact your doctor immediately, as these infections can be life-threatening while taking prednisolone.

Steroid Withdrawal

Do not stop taking prednisolone suddenly if you have been on it for more than 3 weeks. Your dose must be reduced gradually to avoid a serious adrenal crisis.

Steroid Emergency Card

You must carry a Steroid Treatment Card or MedicAlert identification at all times to alert healthcare professionals that you are taking a high-dose steroid in case of an emergency.

Alcohol

It is best to avoid or strictly limit alcohol while taking colecalciferol. Long-term heavy alcohol use can interfere with how your body absorbs and processes Vitamin D, making the treatment less effective.

It is best to avoid or strictly limit alcohol while taking prednisolone. Both alcohol and prednisolone can irritate the lining of the stomach, and using them together increases your risk of developing stomach ulcers or indigestion. Additionally, long-term use of both can increase the risk of thinning bones (osteoporosis).

Caffeine (Coffee, Tea, Energy Drinks)

Prednisolone can increase the effects of caffeine. You may find that you feel more jittery, anxious, or have trouble sleeping if you consume caffeine while taking this medicine. It is also worth noting that both caffeine and prednisolone can increase stomach acid, potentially leading to stomach upset.

Salt (Sodium)

Prednisolone can cause your body to retain salt and water, which may lead to swelling (oedema) and increased blood pressure. It is advisable to limit your intake of very salty foods, such as processed meats, crisps, and canned soups, while on this medication.

Sugary Foods

Prednisolone can increase your blood sugar levels. If you have diabetes, you may need to monitor your blood glucose more closely. Even if you do not have diabetes, it is sensible to avoid excessive amounts of sugary foods and drinks.

High-fat meals

Colecalciferol is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy).

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.