Can I take Colecalciferol and Sertraline together?

It is safe to take colecalciferol (vitamin D) and sertraline together. They are processed by different pathways in the body and do not interfere with each other's absorption, metabolism, or effects.

What you should do

You can continue to take both medications as prescribed by your doctor. No special precautions or monitoring are required for this specific combination.

Serotonin syndrome

Do not take this medicine with other drugs that increase serotonin (such as St John’s Wort or certain painkillers such as tramadol), as this can cause a life-threatening reaction called serotonin syndrome.

Bleeding disorders

This medicine increases your risk of bleeding. You must be extremely cautious if you take blood-thinning medications (such as warfarin) or NSAIDs (such as ibuprofen), as it can lead to serious internal bleeding.

Low sodium levels (hyponatremia)

Sertraline can cause a serious drop in blood sodium levels, especially in older patients or those taking diuretics.

Seek medical help if you experience extreme confusion, weakness, or unsteady gait.

Hypercalcaemia (high blood calcium)

Do not take colecalciferol if you have high levels of calcium in your blood or urine, or if you have severe kidney stones, as vitamin D increases calcium absorption and can worsen these conditions.

Alcohol

It is best to avoid or strictly limit alcohol while taking colecalciferol. Long-term heavy alcohol use can interfere with how your body absorbs and processes Vitamin D, making the treatment less effective.

It is best to avoid or strictly limit alcohol while taking sertraline. Combining alcohol with this medicine can increase side effects like drowsiness, dizziness, and impaired coordination. It may also make your depression or anxiety symptoms worse.

Grapefruit juice

You should avoid drinking large amounts of grapefruit juice while taking sertraline. Grapefruit contains compounds that can increase the level of sertraline in your blood, which may increase the risk of side effects.

Caffeine

Sertraline can sometimes cause jitteriness or difficulty sleeping. High amounts of caffeine can make these side effects worse. If you feel anxious or have trouble sleeping, you may want to limit your caffeine intake.

High-fat meals

Colecalciferol is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy).

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.