Can I take Colecalciferol; cholecalciferol and Ezetimibe together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known significant interaction between colecalciferol (Vitamin D3) and ezetimibe. Taking these two medications together is generally considered safe.
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Why this happens
Ezetimibe works by reducing the absorption of cholesterol in the small intestine. While it affects how the body handles certain fats, studies have shown it does not significantly interfere with the absorption or effectiveness of fat-soluble vitamins like colecalciferol. Similarly, colecalciferol does not change how ezetimibe is processed or cleared by the body.
What you should do
You can continue to take both medications as prescribed by your doctor. No special precautions or timing adjustments are necessary for this specific combination.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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