Can I take Colesevelam and Naproxen together?

Why this happens

Colesevelam is a 'bile acid sequestrant' designed to bind to substances in your digestive system. It can accidentally trap naproxen molecules, preventing them from entering your bloodstream.

You should separate the doses of these two medicines. Take your naproxen at least 4 hours before or 4 hours after you take your colesevelam. This gives the naproxen enough time to be absorbed by your body.

Asthma

Do not take naproxen if you have asthma or a history of wheezing triggered by aspirin or other anti-inflammatory drugs, as it can cause a life-threatening asthma attack.

Stomach ulcers or bleeding

Naproxen significantly increases the risk of stomach ulcers and internal bleeding. Seek immediate medical help if you pass black, tarry stools or vomit blood.

Bowel obstruction or high triglycerides

Do not take colesevelam if you have a history of bowel obstruction or very high triglyceride levels, as it can cause severe constipation or trigger acute pancreatitis.

Taking other oral medicines

Colesevelam can stop other medicines from being absorbed. You must take other medicines at least 1 hour before or 4 hours after taking colesevelam.

Alcohol

Drinking alcohol while taking naproxen can increase the risk of stomach irritation and serious side effects like stomach ulcers or bleeding. It is best to limit or avoid alcohol while on this medication.

It is best to avoid or strictly limit alcohol while taking colesevelam. Alcohol can increase triglyceride levels, which may counteract the effects of the medicine. Additionally, alcohol can increase the risk of gastrointestinal side effects like indigestion or stomach pain.

Fat-soluble vitamins (A, D, E, K)

Colesevelam can interfere with the absorption of fat-soluble vitamins from your food. It is often recommended to take this medicine with a meal to help it work, but you should monitor for signs of vitamin deficiency if taking it long-term.

Food (General)

You should take naproxen with or just after a meal or a snack. This helps to protect your stomach lining and reduces the risk of indigestion or stomach pain.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.