Can I take Cordyceps and Royal sun together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
Both Cordyceps and Royal Sun (Agaricus blazei) are medicinal mushrooms that can thin the blood and lower blood sugar levels. Taking them together may increase the risk of bruising, bleeding, or your blood sugar dropping too low (hypoglycaemia).
Why this happens
These supplements have 'additive' effects. This means they work in similar ways to slow down blood clotting and improve how the body handles insulin. When combined, these effects can become stronger than intended.
What you should do
If you choose to take both, monitor your blood sugar levels closely (if you are diabetic) and watch for signs of easy bruising or bleeding gums. If you have an upcoming surgery, stop taking both at least two weeks before the procedure. Consult your doctor if you are already taking prescribed blood thinners or diabetes medication.
Important precautions
Auto-immune conditions (e.g., multiple sclerosis, lupus, rheumatoid arthritis)
These supplements can increase immune system activity, which may worsen the symptoms of autoimmune diseases. Avoid use if you have these conditions.
Bleeding disorders or upcoming surgery
Both supplements may slow blood clotting and increase the risk of bleeding during and after surgery. You must stop taking them at least 2 weeks before any scheduled surgical procedure.
Diabetes (on medication)
These supplements can lower blood sugar levels. When taken with insulin or other diabetes medicines, they may cause your blood sugar to drop dangerously low (hypoglycaemia).
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking these supplements. Both Cordyceps and Royal Sun mushrooms may affect liver function or blood sugar levels, and alcohol can increase the risk of liver strain or cause unpredictable changes in blood sugar.
Caffeine (Coffee, Tea, Energy Drinks)
Cordyceps may have mild stimulant properties. Consuming caffeine alongside this supplement may increase feelings of jitteriness, rapid heartbeat, or difficulty sleeping.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Flecainide and Wegovy together?
Wegovy (semaglutide) can slow down how quickly your stomach empties. This might change how your body absorbs flecainide, which is a medicine that needs to be kept at very specific levels in your blood to work safely and effectively. Additionally, both medications can occasionally affect your heart rhythm or heart rate.

Drug interactions checker
Can I take Mounjaro and Metformin together?
When taken together, Mounjaro and Metformin can increase the risk of your blood sugar levels dropping too low (hypoglycaemia). While both drugs work to lower blood sugar, they do so in different ways, which can sometimes lead to an additive effect. Additionally, Mounjaro slows down how quickly your stomach empties, which might slightly change how your body absorbs Metformin, though this is usually not a major concern.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Adcal-D3 and Collagen together?
- Can I take Amitriptyline and Trazodone together?
- Can I take Ashwagandha and Vitamin B12 together?
- Can I take Atorvastatin and Pyridostigmine together?
- Can I take Black cohosh and Vitamin C together?
- Can I take Black garlic and Vitamin C together?
- Can I take Calcium and Esomeprazole together?
- Can I take Chaga and Cordyceps together?
- Can I take Colecalciferol and Tizanidine together?
- Can I take Collagen and Omega-3 together?
- Can I take Flecainide and Lansoprazole together?
- Can I take Gabapentin and Ibuprofen together?
- Can I take Lansoprazole and Rivaroxaban together?
- Can I take Losartan and Paracetamol together?
- Can I take Magnesium and Wegovy flextouch together?
- Can I take Mounjaro and Insulin together?
- Can I take Pregabalin and Trazodone together?
- Can I take Rivaroxaban and Tamsulosin together?
- Can I take St John's wort and Vitamin B12 together?
- Can I take Vitamin B12 and Vitamin B2 together?