Can I take Danazol and Naproxen together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking danazol and naproxen together may increase the risk of fluid retention (swelling) and could potentially increase the strain on your kidneys. There is also a small possibility that danazol could increase the levels of naproxen in your blood, making side effects like stomach irritation more likely.
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Why this happens
Danazol can cause the body to hold onto salt and water (fluid retention), which is a side effect also shared by NSAIDs like naproxen. Additionally, danazol may interfere with the liver enzymes (CYP enzymes) that help break down naproxen, potentially leading to higher levels of the painkiller in your system.
What you should do
You can usually take these together, but you should monitor yourself for signs of fluid retention, such as swollen ankles or sudden weight gain. If you have existing heart, kidney, or liver problems, speak to your doctor before combining them. Always take naproxen with food to protect your stomach.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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