Can I take Devil's claw and Vitamin C together?
Drug interaction guide
Originally published 25 Jan 2026
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There are no known significant interactions between devil's claw and vitamin C. It is generally considered safe to take these two supplements together.
Why this happens
Devil's claw and vitamin C are processed by the body through different pathways and do not interfere with each other's absorption, metabolism, or effects.
What you should do
You can continue taking both supplements as directed. However, always inform your doctor or pharmacist about all supplements you are taking, especially if you have underlying health conditions like stomach ulcers or kidney stones.
Important precautions
Stomach ulcers or gallstones
Devil's claw can increase stomach acid and stimulate bile production, which may worsen stomach ulcers, duodenal ulcers, or gallstones.
Diabetes
Devil's claw may lower blood sugar levels; you must monitor your blood glucose closely as your diabetes medication dosage may need adjustment.
Heart rhythm disorders (arrhythmias)
Devil's claw can affect heart rate and blood pressure; use with caution if you have a heart condition or take blood pressure medication.
Kidney stones (oxalate)
High doses of vitamin C can increase the amount of oxalate in your urine, significantly raising the risk of developing kidney stones, especially if you have a history of them.
G6PD deficiency
If you have glucose-6-phosphate dehydrogenase (G6PD) deficiency, high doses of vitamin C can cause your red blood cells to break down (haemolysis).
Haemochromatosis
Vitamin C increases the absorption of iron from your food. If you have an iron-overload disorder like haemochromatosis, you should avoid high-dose supplements.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking Devil's Claw. Devil's Claw can increase the production of stomach acid, and alcohol is a known stomach irritant. Combining them may increase the risk of stomach upset, irritation, or gastric ulcers. Additionally, both substances are processed by the liver; combining them may increase the strain on liver function.
Caffeine (Coffee, Tea, Energy Drinks)
High doses of vitamin C may slightly increase the rate at which your body breaks down caffeine. This could potentially reduce the effects of caffeine, though this is usually only significant with very high supplemental doses of the vitamin.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

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