Can I take Ezetimibe and Indapamide together?

Why this happens

Ezetimibe works in the digestive tract to reduce cholesterol absorption, while indapamide is a diuretic (water tablet) that works on the kidneys to lower blood pressure. They are processed by different pathways in the body and do not interfere with how the other is absorbed, broken down, or excreted.

What you should do

You can continue to take both medications as prescribed by your doctor. As with any medication, if you notice any new or unusual symptoms, such as extreme muscle pain or severe dizziness, you should mention this to your healthcare provider during your next check-up.

Important precautions

Liver disease

You must not take ezetimibe if you have moderate or severe liver disease. If you develop unexplained muscle pain, tenderness, or weakness while taking it, contact your doctor immediately, as this can rarely lead to serious muscle breakdown.

Sulphonamide allergy

Do not take this medicine if you are allergic to sulphonamide antibiotics (such as sulfamethoxazole), as you may have a similar allergic reaction to indapamide.

Low potassium (Hypokalaemia)

Indapamide can significantly lower your blood potassium levels. Your doctor must monitor this, especially if you have heart rhythm problems, as low potassium increases the risk of dangerous heart arrhythmias.

Unexplained muscle pain - ezetimibe

You must contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness. While rare, this can be a sign of serious muscle breakdown, especially if taken alongside a statin.

Food and drink warnings

Alcohol

Drinking alcohol while taking indapamide can increase the blood pressure-lowering effect of the medicine. This may make you feel dizzy, lightheaded, or faint, especially when standing up quickly. It is best to keep your alcohol intake within recommended limits and see how the medicine affects you before drinking.

It is best to avoid or strictly limit alcohol while taking ezetimibe. Both alcohol and ezetimibe can affect your liver; combining them may increase the risk of liver damage or inflammation. If you have a history of liver disease, you should be particularly cautious.

Salt (Sodium)

Eating a diet very high in salt can make indapamide less effective at lowering your blood pressure. Try to limit high-salt foods like processed meats, canned soups, and salty snacks.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.