Can I take Folitrax and Predmet together?

Why this happens

Both medicines suppress the immune system in different ways. While this helps treat your condition, it also makes it harder for your body to fight off germs. Additionally, steroids like Predmet can sometimes affect how the kidneys clear Folitrax from your body, potentially leading to higher levels of the medicine in your blood.

You can take these together if prescribed by your doctor, but you must be closely monitored. Tell your doctor immediately if you develop signs of infection, such as a fever, sore throat, or persistent cough. You will need regular blood tests to check your liver function and blood cell counts. Do not start any new medicines or vaccines without checking with your specialist first.

Pregnancy and conception

You must not take this medicine if you are pregnant or planning to become pregnant, as it causes severe birth defects. Both men and women must use effective contraception during treatment and for at least 6 months after stopping.

Infection risk and vaccinations

These medicines suppress your immune system. You must avoid 'live' vaccines and seek urgent medical help if you develop signs of infection (like fever or sore throat) or if you are exposed to chickenpox or shingles.

Blood, liver, or lung toxicity

You must report any unusual bruising, bleeding, yellowing of the skin, or a persistent new cough immediately, as these can be signs of serious blood, liver, or lung damage.

Alcohol

You must strictly limit or avoid alcohol while taking methotrexate. Both alcohol and methotrexate can cause liver damage, and combining them significantly increases the risk of serious liver toxicity and scarring (cirrhosis).

Caffeine (Coffee, Tea, Cola)

High amounts of caffeine may reduce the effectiveness of methotrexate in treating conditions like rheumatoid arthritis. Try to keep your intake of coffee, tea, and caffeinated soft drinks consistent and moderate.

Grapefruit juice

Grapefruit and grapefruit juice can increase the amount of methylprednisolone in your blood, which may increase the risk of side effects. It is best to avoid grapefruit products while taking this medicine.

Salt (Sodium)

Steroids like methylprednisolone can cause your body to retain salt and water, leading to swelling and high blood pressure. You may be advised to reduce your salt intake while on this medication.

Sugary foods and drinks

Methylprednisolone can increase your blood sugar levels. If you have diabetes, or are at risk of it, you should monitor your sugar intake and blood glucose levels closely.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.