Can I take Furosemide and Vitamin d3 1000 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking furosemide and Vitamin D3 together can sometimes lead to high levels of calcium in your blood (hypercalcaemia). While furosemide usually helps the body get rid of calcium, Vitamin D3 increases how much calcium your body absorbs. If you take very high doses of Vitamin D, it could potentially interfere with how the furosemide works or affect your kidney function.
In this article:
Continue reading below
Why this happens
Furosemide is a 'loop diuretic' that typically causes the kidneys to excrete calcium. Vitamin D3 (cholecalciferol) works by increasing the absorption of calcium from your food and preventing calcium loss. When used together, these opposing effects can occasionally lead to an imbalance in your blood mineral levels, particularly if you have underlying kidney issues.
What you should do
For most people, a standard dose of 1000 IU of Vitamin D3 is safe to take with furosemide. However, you should have your blood monitored regularly by your doctor to check your calcium levels and kidney function. If you experience symptoms like extreme thirst, frequent urination, confusion, or unusual tiredness, contact your GP. Do not start any new high-dose calcium supplements without speaking to your doctor first.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Idapamide and Ramipril together?
Taking indapamide and ramipril together can cause your blood pressure to drop too low, especially when you first start the combination. This can make you feel dizzy, lightheaded, or faint. It can also put extra strain on your kidneys.

Treatment and medication
Can I take Clarithromycin and Rosuvastatin together?
Taking these two medicines together can significantly increase the amount of rosuvastatin in your blood. This increases the risk of serious muscle damage (rhabdomyolysis), which can lead to kidney problems. Symptoms to watch for include unexplained muscle pain, tenderness, or weakness, especially if you also feel generally unwell or have a fever.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.