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Can I take Furosemide and Vitamin d3 1000 together?

Drug interaction guide

Taking furosemide and Vitamin D3 together can sometimes lead to high levels of calcium in your blood (hypercalcaemia). While furosemide usually helps the body get rid of calcium, Vitamin D3 increases how much calcium your body absorbs. If you take very high doses of Vitamin D, it could potentially interfere with how the furosemide works or affect your kidney function.

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Why this happens

Furosemide is a 'loop diuretic' that typically causes the kidneys to excrete calcium. Vitamin D3 (cholecalciferol) works by increasing the absorption of calcium from your food and preventing calcium loss. When used together, these opposing effects can occasionally lead to an imbalance in your blood mineral levels, particularly if you have underlying kidney issues.

What you should do

For most people, a standard dose of 1000 IU of Vitamin D3 is safe to take with furosemide. However, you should have your blood monitored regularly by your doctor to check your calcium levels and kidney function. If you experience symptoms like extreme thirst, frequent urination, confusion, or unusual tiredness, contact your GP. Do not start any new high-dose calcium supplements without speaking to your doctor first.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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