Can I take Hydroxocobalamin and Clopidogrel together?

Why this happens

These medications are processed by different pathways in the body. Hydroxocobalamin is a vitamin used for red blood cell production and nerve health, while clopidogrel is an antiplatelet medicine used to prevent blood clots. They do not interfere with how each other is absorbed, broken down, or excreted.

You can continue to take both medications as prescribed by your doctor. No special precautions or timing adjustments are necessary.

Upcoming surgery or dental work

You must tell your surgeon or dentist you are taking clopidogrel at least 7 days before any planned procedure, as it increases your risk of bleeding and may need to be stopped temporarily.

Stomach ulcers or bleeding disorders

Do not take clopidogrel if you have an active stomach ulcer or any condition causing internal bleeding, as it prevents blood clotting and can make bleeding life-threatening.

Hypokalaemia (low potassium)

When starting treatment for severe vitamin B12 deficiency, your potassium levels can drop rapidly as your body produces new red blood cells. This can be dangerous for your heart and may require monitoring by your doctor.

Alcohol

It is best to avoid or strictly limit alcohol while taking clopidogrel. Both alcohol and clopidogrel can irritate the stomach lining and increase the risk of internal bleeding or stomach ulcers.

It is best to avoid or strictly limit alcohol while receiving hydroxocobalamin treatment. Excessive alcohol consumption can interfere with the absorption of Vitamin B12 and may worsen the underlying deficiency being treated. Combining alcohol with medication also increases the risk of liver strain.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.