Can I take Ibuprofen lysine and Paracetamol together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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It is safe to take ibuprofen lysine and paracetamol together. These two medicines work in different ways to relieve pain and reduce fever. Taking them together can often provide better pain relief than taking either one alone.
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Why this happens
Paracetamol and ibuprofen belong to different classes of painkillers. Paracetamol works mainly in the central nervous system to block pain signals, while ibuprofen (an NSAID) reduces inflammation and pain at the site of the injury. Because they work through different pathways, they do not interfere with how the body absorbs or processes each other.
What you should do
You can take these medicines at the same time or stagger them. Always follow the dosage instructions on the packaging for each product. Ensure you do not take more than the maximum daily dose for either medicine. If you are using a 'combination' product that already contains both, do not take extra paracetamol or ibuprofen on top of it.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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