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Can I take Lactulose and Pregabalin together?

Drug interaction guide

There are no known direct interactions between lactulose and pregabalin. It is generally safe to take these two medicines together.

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Why this happens

Lactulose is a laxative that works locally in the bowel and is not absorbed into the bloodstream. Pregabalin is absorbed into the blood to work on the nervous system and is cleared by the kidneys. Because they work in different ways and do not interfere with how the body processes each other, no interaction occurs.

What you should do

You can continue to take both medicines as prescribed. However, be aware that pregabalin can sometimes cause constipation as a side effect; if your constipation does not improve while using lactulose, you should speak with your doctor or pharmacist.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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