Can I take Lansoprazole and Naproxen together?

Why this happens

Lansoprazole increases the pH (reduces the acidity) of the stomach. Because naproxen needs a certain level of acidity to dissolve and be absorbed efficiently, the presence of lansoprazole can slightly alter its absorption profile. This is generally considered a 'beneficial' interaction because the protective effect on the stomach outweighs the minor change in drug absorption.

What you should do

It is safe and common to take these together. In fact, if you are taking naproxen long-term, your doctor likely prescribed lansoprazole specifically to prevent stomach ulcers. Take them exactly as directed by your healthcare professional. If you notice any unusual stomach pain or black, tarry stools, contact your doctor immediately.

Important precautions

Asthma

Do not take naproxen if you have a history of asthma or wheezing triggered by aspirin or other NSAIDs, as it can cause a life-threatening asthma attack.

Pregnancy (third trimester)

Naproxen must not be taken if you are more than 20 weeks pregnant as it can cause serious heart or kidney problems in the unborn baby and reduce amniotic fluid levels.

Stomach ulcers or bleeding

Naproxen significantly increases the risk of stomach ulcers and bleeding. Lansoprazole is often prescribed alongside it to reduce this risk, so it is vital to take both as directed.

Severe diarrhoea

Lansoprazole can increase your risk of serious bowel infections. If you develop severe or persistent watery diarrhoea, or a fever, contact your doctor immediately and do not take anti-diarrhoeal medicine.

Lupus (SLE) or skin reactions

Contact your doctor if you develop a skin rash, especially in areas exposed to the sun, as lansoprazole can cause a rare but serious autoimmune skin reaction.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking lansoprazole. Alcohol increases the amount of acid your stomach produces, which can make your symptoms worse and counteract the effects of the medicine.

It is best to avoid or strictly limit alcohol while taking naproxen. Both alcohol and naproxen can irritate the lining of your stomach; combining them significantly increases the risk of stomach ulcers and internal bleeding.

Food (Timing)

Lansoprazole works best if you take it at least 30 minutes before food. Taking it with or after food can make it less effective at reducing stomach acid.

You should take naproxen with or just after a meal or a snack. This helps to protect your stomach lining and reduces the risk of indigestion or stomach pain.

Caffeine (Coffee, Tea, Energy Drinks)

Caffeine can increase stomach acid production and irritate the stomach lining. This may worsen the conditions these medicines are treating (such as acid reflux or stomach sensitivity) and may increase the risk of indigestion.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.