Can I take Levothyroxine and Xarelto together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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There is no known direct interaction between levothyroxine and Xarelto (rivaroxaban). Taking these two medications together is generally considered safe.
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Why this happens
Levothyroxine is a synthetic version of a thyroid hormone, while Xarelto is an anticoagulant (blood thinner). They are processed by different pathways in the body and do not interfere with how the other is absorbed, broken down, or excreted.
What you should do
Back to contentsYou can continue taking both medications as prescribed by your doctor. It is important to maintain a consistent routine with your levothyroxine (usually taken on an empty stomach, 30 to 60 minutes before breakfast) to ensure your thyroid levels remain stable. If your thyroid levels become very high (hyperthyroidism) or very low (hypothyroidism) due to dose changes, your doctor may want to monitor your overall health more closely, as thyroid function can occasionally influence how the body responds to blood thinners in general.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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