Can I take Lion's mane and Maitake together?
Drug interaction guide
Originally published 25 Jan 2026
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Both lion's mane and maitake mushrooms can lower blood sugar levels and thin the blood. Taking them together might increase the risk of your blood sugar dropping too low (hypoglycaemia) or make you bruise or bleed more easily.
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Why this happens
These supplements have 'additive' effects. This means they work in similar ways to affect blood clotting and glucose metabolism. When combined, their individual effects are added together, making the overall impact on your body stronger.
What you should do
It is generally safe to take these together in standard culinary or supplement amounts, but you should monitor yourself for signs of low blood sugar (such as feeling shaky, sweaty, or dizzy) and unusual bruising. If you are scheduled for surgery, stop taking both at least two weeks beforehand. If you already take medication for diabetes or blood-thinning drugs (like warfarin), speak to your doctor before combining these supplements.
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Important precautions
Surgery
Stop taking these at least 2 weeks before any scheduled surgery. Both mushrooms can thin the blood and increase the risk of excessive bleeding during and after procedures.
Diabetes
Maitake can significantly lower blood sugar levels. If you take insulin or oral diabetes medication, you must monitor your blood glucose closely to avoid dangerous hypoglycaemia (low blood sugar).
Food and drink warnings
Alcohol
Maitake may lower blood sugar levels. Consuming alcohol while taking maitake can increase the risk of hypoglycaemia (low blood sugar), as alcohol also interferes with blood sugar regulation. Symptoms include dizziness, shakiness, and confusion.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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