Can I take Lion's mane and Maitake together?
Drug interaction guide
Originally published 25 Jan 2026
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Both Lion's Mane and Maitake mushrooms may lower blood sugar levels and slow down blood clotting. Taking them together might increase the risk of your blood sugar dropping too low (hypoglycaemia) or increase the chance of bruising and bleeding.
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Why this happens
These supplements have 'additive' effects. This means they work in similar ways: both contain compounds (like beta-glucans) that can improve insulin sensitivity and others that may prevent blood platelets from sticking together. When combined, these effects can become stronger.
What you should do
Back to contentsThis combination is usually fine for most healthy people, but you should use caution. If you have diabetes or take blood-thinning medication (like warfarin or aspirin), speak to your doctor before mixing them. Monitor your blood sugar levels closely and watch for signs of easy bruising or nosebleeds. If you have an upcoming surgery, stop taking both at least two weeks beforehand.
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Important precautions
Back to contentsSurgery
Stop taking these supplements at least 2 weeks before any scheduled surgery. Both lion's mane and maitake may slow blood clotting, which increases your risk of excessive bleeding during and after the procedure.
Diabetes
Maitake can lower your blood sugar levels. If you are taking insulin or other diabetes medications, using maitake may cause your blood sugar to drop too low (hypoglycaemia). You must monitor your blood sugar closely.
Food and drink warnings
Back to contentsAlcohol
It is best to avoid or strictly limit alcohol when taking Lion's Mane. While there is limited clinical data on the specific interaction, both substances can affect the central nervous system. Combining them may increase the risk of drowsiness or dizziness. Additionally, alcohol can cause inflammation that may counteract the potential neuroprotective benefits of the supplement.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
Can I take Lisinopril and Potassium together?
Taking lisinopril and potassium supplements together can cause the levels of potassium in your blood to become dangerously high (a condition called hyperkalaemia). While your body needs potassium for your heart and muscles to work, too much of it can lead to serious heart rhythm problems or even cause the heart to stop. Symptoms of high potassium can include muscle weakness, tingling sensations, or palpitations, but often there are no symptoms until the level is very high.
Treatment and medication
Can I take Lion's mane and Shiitake together?
There are no known harmful interactions between Lion's Mane (Hericium erinaceus) and Shiitake (Lentinula edodes) mushrooms. Both are commonly consumed together as food or supplements.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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