Can I take Lion's mane and Maitake together?

Why this happens

These supplements have 'additive' effects. This means they work in similar ways: both contain compounds (like beta-glucans) that can improve insulin sensitivity and others that may prevent blood platelets from sticking together. When combined, these effects can become stronger.

What you should do

This combination is usually fine for most healthy people, but you should use caution. If you have diabetes or take blood-thinning medication (like warfarin or aspirin), speak to your doctor before mixing them. Monitor your blood sugar levels closely and watch for signs of easy bruising or nosebleeds. If you have an upcoming surgery, stop taking both at least two weeks beforehand.

Important precautions

Surgery

Stop taking these supplements at least 2 weeks before any scheduled surgery. Both lion's mane and maitake may slow blood clotting, which increases your risk of excessive bleeding during and after the procedure.

Diabetes

Maitake can lower your blood sugar levels. If you are taking insulin or other diabetes medications, using maitake may cause your blood sugar to drop too low (hypoglycaemia). You must monitor your blood sugar closely.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking Lion's Mane. While there is limited clinical data on the specific interaction, both substances can affect the central nervous system. Combining them may increase the risk of drowsiness or dizziness. Additionally, alcohol can cause inflammation that may counteract the potential neuroprotective benefits of the supplement.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.