Can I take Lions mane and Reisha together?
Drug interaction guide
Originally published 25 Jan 2026
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Both Lion's Mane and Reishi mushrooms have natural blood-thinning properties. Taking them together might increase the risk of bruising or bleeding, especially if you are already taking blood-thinning medication or have an upcoming surgery. Additionally, both may lower blood sugar levels, which could lead to feeling dizzy or shaky if levels drop too low.
In this article:
It is usually fine to take Lions Mane and Reisha together. However, using both might increase the risk of bruising or bleeding, especially if you are already taking blood-thinning medication or have an upcoming surgery.
Stop taking both supplements at least two weeks before any planned surgery.
If you take medicine for diabetes, blood pressure, or blood thinners (such as warfarin or aspirin), talk to your doctor before using them together.
Watch for signs of low blood sugar or unusual bruising.
Why this happens
Both supplements can slow down blood clotting (antiplatelet effect) and improve how the body uses insulin (hypoglycaemic effect). When used together, these effects can add up, making them stronger than when taken alone.
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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