Skip to main content

Can I take Lipitor and Zentiva clopidogrel together?

Drug interaction guide

Taking Lipitor (atorvastatin) and clopidogrel together may slightly reduce the effectiveness of clopidogrel in preventing blood clots. However, for most people, the benefits of taking both medicines to prevent heart attacks or strokes far outweigh this small risk.

Continue reading below

Why this happens

Both medicines are processed by the same enzyme in the liver (CYP3A4). Because Lipitor uses this enzyme, it can slow down the process that turns clopidogrel into its active form, potentially making clopidogrel slightly less effective at 'thinning' the blood.

What you should do

You should continue taking both medicines as prescribed by your doctor. Do not stop taking either medication without medical advice, as they are often prescribed together to protect your heart. Your doctor is likely already aware of this interaction and has determined it is safe for you. If you have concerns, or if you notice any new signs of blood clots (such as sudden leg pain or shortness of breath), speak to your GP.

Continue reading below

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Continue reading below

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.