Can I take Magnesium and Mirtazapine together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking magnesium and mirtazapine together may increase feelings of sleepiness, drowsiness, or dizziness.
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Why this happens
Both magnesium and mirtazapine have calming effects on the central nervous system. Magnesium can act as a mild muscle relaxant and sedative, while mirtazapine is an antidepressant known for causing significant drowsiness. When used together, these effects can add up.
What you should do
Back to contentsIt is generally safe to take these together, but you should be aware that you might feel more tired than usual. It is best to take both substances in the evening or before bed. Avoid driving or operating heavy machinery until you know how this combination affects you. If you feel excessively drowsy the next day, speak to your doctor about adjusting the timing or dose.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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