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Can I take Metformin and Rybelsus together?

Drug interaction guide

Taking metformin and Rybelsus (semaglutide) together can increase the risk of your blood sugar levels dropping too low (hypoglycaemia). You may also experience more stomach-related side effects like nausea or diarrhoea.

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Why this happens

Both medicines work in different ways to lower blood sugar. Metformin reduces the amount of sugar your liver produces, while Rybelsus helps your body release more insulin when you eat. When used together, their effects are additive, meaning they work together to lower blood sugar more than either would alone.

What you should do

It is very common for these two medicines to be prescribed together. However, you should monitor your blood sugar levels regularly as your doctor advises. Learn to recognise the signs of low blood sugar (such as feeling shaky, sweaty, hungry, or dizzy) and always carry a fast-acting sugar source. If you experience severe or persistent stomach upset, speak to your doctor.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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