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Can I take Metoprolol and Trazadone together?

Drug interaction guide

Taking metoprolol and trazodone together can cause your blood pressure to drop too low or your heart rate to slow down more than intended. You may feel dizzy, lightheaded, or faint, especially when standing up quickly. There is also a small risk that trazodone could increase the levels of metoprolol in your blood, making its effects stronger.

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Why this happens

Both drugs can lower blood pressure and heart rate (an additive effect). Additionally, trazodone may interfere with the liver enzymes (specifically CYP2D6) that break down metoprolol, potentially leading to higher levels of the heart medication in your system.

You can take these together, but you should be cautious. Monitor your blood pressure and heart rate regularly. When getting out of bed or sitting up, do so slowly to avoid dizziness. If you feel very faint, experience a very slow pulse, or have extreme tiredness, contact your doctor. They may need to adjust your doses.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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