Can I take Naproxen and Oxycodone together?

Why this happens

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that reduces protective chemicals in the stomach lining and affects blood flow to the kidneys. Oxycodone is an opioid painkiller. While they work in different ways to stop pain (additive effect), taking them together does not change how the body breaks them down, but it does increase the overall burden on your internal organs, particularly the digestive system and kidneys.

What you should do

You can take these medicines together if your doctor has specifically prescribed both, but you must use caution. Always take naproxen with food or a glass of milk to protect your stomach. Drink plenty of water to help your kidneys. If you notice any signs of stomach bleeding (such as black, tarry stools or coffee-ground-like vomit) or severe indigestion, stop taking the naproxen and contact your doctor immediately. Do not take more than the recommended dose of either medication.

Important precautions

Opioid addiction and respiratory depression

Oxycodone is highly addictive and can lead to dependence. Taking too much, or mixing it with alcohol or benzodiazepines, can cause dangerously slow or shallow breathing which can be fatal.

Asthma

Do not take naproxen if you have asthma that is sensitive to aspirin or other NSAIDs, as it can trigger a life-threatening asthma attack or severe breathing difficulties.

Stomach ulcers or bleeding

Naproxen can cause serious stomach ulcers and internal bleeding. This risk is higher if you have had ulcers before, are over 65, or take other blood-thinning medicines. Stop taking it and see a doctor immediately if you have black, tarry stools or vomit blood.

Pregnancy (third trimester)

Do not take naproxen if you are more than 20 weeks pregnant. It can cause serious kidney or heart problems in the unborn baby and may lead to complications during delivery.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking oxycodone. Combining alcohol with this medicine significantly increases the risk of dangerous side effects, such as severe drowsiness, breathing difficulties, and a potentially fatal overdose.

It is best to avoid or strictly limit alcohol while taking naproxen. Both alcohol and naproxen can irritate the lining of your stomach; combining them significantly increases your risk of developing stomach ulcers or internal bleeding.

Grapefruit juice

Avoid drinking grapefruit juice or eating grapefruit while taking oxycodone. Grapefruit can interfere with how your body breaks down the medicine, leading to higher levels of the drug in your blood and increasing the risk of serious side effects.

Food (General)

You should take naproxen with or just after a meal or a snack. This helps to protect your stomach lining and reduces the risk of indigestion or stomach pain.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.