Can I take Omeprazole and Tramadol together?

Why this happens

Tramadol needs to be broken down by a specific enzyme in the liver (called CYP2D6) to turn into its most active, pain-killing form. Omeprazole can mildly interfere with this process. Additionally, both drugs can occasionally affect serotonin levels, though this is rare at standard doses.

You can usually take these two medicines together. However, if you find that your pain is not being controlled as well as usual, or if you feel unusually sleepy or dizzy, speak to your doctor or pharmacist. Do not change your dose without medical advice.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.