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Can I take Omeprazole and Vitamin b12 together?

Drug interaction guide

Taking omeprazole for a long time can make it harder for your body to absorb vitamin B12 from the food you eat. Over several years, this could lead to a vitamin B12 deficiency.

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Why this happens

Vitamin B12 is naturally bound to proteins in food. To release the vitamin so your body can use it, you need stomach acid. Omeprazole works by reducing the amount of acid your stomach produces. With less acid available, the B12 stays 'locked' in the food and passes through your system without being fully absorbed.

What you should do

If you take omeprazole for more than 2 to 3 years, ask your doctor to check your vitamin B12 levels with a blood test. You should also watch for signs of low B12, such as feeling very tired, having a sore tongue, or feeling 'pins and needles'. If you need a supplement, high-dose oral tablets or B12 injections usually work well because they don't rely as much on stomach acid for absorption.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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