Can I take Per and 12.5mg together?

Why this happens

Both drugs can have a mild depressing effect on the central nervous system. Amitriptyline is a tricyclic antidepressant that often causes sedation, and while paracetamol is a painkiller, combining it with other medications or alcohol can increase the strain on your liver and your level of tiredness.

You can take these two medicines together, but be aware that you may feel extra drowsy. Do not drive or operate machinery until you are certain you are not impaired. It is best to avoid or strictly limit alcohol, as drinking while taking paracetamol increases the risk of liver damage, and alcohol will significantly worsen the sedative effects of amitriptyline.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.