Can I take Pregabalin and Shortec together?

Why this happens

Both drugs are 'central nervous system depressants'. Pregabalin works by calming overactive nerves, while Shortec (an opioid) works by blocking pain signals in the brain. Because they both slow down brain activity and the signals that control breathing, they have an 'additive' effect, meaning they 'double up' on these side effects.

What you should do

You should only take these two medicines together if they have been specifically prescribed this way by your doctor. If you are taking both, start with the lowest possible doses. Avoid driving or operating machinery until you know how the combination affects you. Seek urgent medical help if you experience extreme sleepiness, confusion, or slow, shallow breathing. Avoid drinking alcohol while taking these medications.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.