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Can I take Sedoxil and Venlafaxine together?

Drug interaction guide

Taking these two medicines together can make you feel very sleepy, dizzy, or confused. It can also make it harder to concentrate or perform tasks that require alertness, such as driving. In some cases, it may cause breathing to become slower or shallower.

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Why this happens

Both Sedoxil (mexazolam) and venlafaxine have effects on the central nervous system. Sedoxil is a benzodiazepine that slows down brain activity to reduce anxiety, while venlafaxine is an antidepressant that can also have sedative effects. When used together, their calming effects on the brain are added together (an additive effect).

What you should do

You should use this combination with caution. Avoid driving or operating heavy machinery until you know how these medicines affect you. Do not drink alcohol while taking these medications, as it will make the sleepiness much worse. If you feel excessively drowsy or have trouble breathing, contact your doctor immediately.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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