Celecoxib capsules for pain and inflammation
Celebrex
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 15 Apr 2023
Meets Patient’s editorial guidelines
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Celecoxib is a medicine called a non-steroidal anti-inflammatory drug. It is also known as an 'NSAID'.
Before you take celecoxib, let your doctor know if you have ever had a bad reaction to any other anti-inflammatory painkiller.
The most common side effects of celecoxib include diarrhoea, indigestion, abdominal pain, and feeling sick (nausea).
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About celecoxib
Type of medicine | A selective inhibitor of cyclo-oxygenase-2 non-steroidal anti-inflammatory drug (NSAID) |
Used for | Relief of pain and inflammation in osteoarthritis, rheumatoid arthritis or ankylosing spondylitis |
Also called | Celebrex® |
Available as | Capsules |
What is celecoxib used for?
Celecoxib is a type of anti-inflammatory painkiller called non-steroidal anti-inflammatory drugs (NSAIDs), or just 'anti-inflammatories'.
It is used to treat painful rheumatic conditions such as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It eases pain and reduces inflammation.
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How does celecoxib work?
Celecoxib reduces pain and swelling by blocking an enzyme (COX-2) that causes inflammation. This helps ease pain and stiffness in arthritis.
Side effects of celecoxib
Common side effects of celecoxib include:
Feeling dizzy.
Diarrhoea.
Headache.
Indigestion.
Farting (wind).
Stomach (abdominal) pain.
Feeling sick.
You will find a full list in the manufacturer's information leaflet supplied with your medicine.
The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any side effects continue or become troublesome.
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How to manage celecoxib side effects
Common celecoxib side effects | What can I do if I experience this? |
Feeling dizzy | Do not drive and do not use tools or machines until you feel better |
Diarrhoea | Drink plenty of water to replace any lost fluids |
Headache | Drink plenty of water. If the headaches continue, speak with your doctor |
Indigestion, wind, stomach pain | Stick to simple meals - avoid rich or spicy foods. If the discomfort continues, speak with your doctor |
High blood pressure, swollen ankles, joint pain, fluid retention, flu-like illness, runny nose, cough, chest or urinary infections, and difficulties sleeping | If any of these become troublesome, speak with your doctor |
Important: if you experience any of the following less common but more serious symptoms, stop taking celecoxib and contact your doctor for advice straightaway:
If you have any breathing difficulties such as wheeze or breathlessness.
If you have any signs of an allergic reaction such as swelling around your mouth or face, or a severe itchy skin rash.
If you pass blood or black stools, bring up (vomit) blood, or have abdominal pains.
If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.
Who should not take celecoxib?
Some medicines aren’t suitable for everyone. Before taking celecoxib, your doctor needs to know:
If you have asthma or any other allergic disorder.
If you have had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis.
If you are pregnant, trying for a baby, or breastfeeding.
If you are under 18 or over 65 years of age.
If you have liver or kidney problems.
If you have a heart condition, or a problem with your blood vessels or circulation.
If you have high blood pressure.
If you have ever had blood clotting problems.
If you have a connective tissue disorder, such as systemic lupus erythematosus (an inflammatory condition also called lupus, or SLE).
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
If you have ever had an allergic reaction to aspirin or other NSAID (such as indometacin, diclofenac, and ibuprofen), or to any other medicine. Or if you are allergic to a sulfonamide medicine.
How to take celecoxib
Read the information leaflet in the pack before starting celecoxib to learn about side effects.
Take celecoxib exactly as prescribed, usually 1 capsule once or twice a day (100 mg or 200 mg).
Take it at the same time(s) each day to help you remember.
Swallow capsules whole with water, or open and mix with soft food if needed, then drink water. You can take it with or without food.
If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not take two doses together.
Getting the most from your treatment
Your doctor will prescribe the lowest dose for the shortest time to reduce side effects.
For long-term use you may be given another medicine to protect your stomach.
Keep regular doctor appointments so your progress and blood pressure can be checked.
Pain should improve within a few days; if not better after two weeks, talk to your doctor.
If you have asthma and develop wheezing or breathlessness, stop taking celecoxib and see a doctor.
Check with a pharmacist before buying other medicines - don’t take celecoxib with other anti-inflammatory painkillers.
If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
How to store celecoxib
Keep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Important information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.
Frequently asked questions
How long does it take for celecoxib to work?
Celecoxib usually starts to work within 30-60 minutes of taking it, with pain relief typically lasting for 12-14 hours. For chronic inflammation, pain and swelling usually begin to improve after a week of regular use.
Can you drink alcohol with celecoxib?
Yes, you can drink small amounts of alcohol with celecoxib, however it can increase the risk of stomach irritation and bleeding. It is best to avoid or limit alcohol until your treatment is finished.
Is it safe to take celecoxib during pregnancy?
Celecoxib is not recommended during pregnancy as it can harm the baby. If you are pregnant or planning to become pregnant, let your doctor know.
Further reading and references
- Manufacturer's PIL, Celebrex® 100 mg and 200 mg Capsules; Upjohn UK Ltd, The electronic Medicines Compendium. Dated January 2021.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 14 Apr 2026
15 Apr 2023 | Latest version

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