Cromolyn sodium nasal spray
Nasalcrom
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 18 Jan 2024
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Cromolyn sodium spray will help to prevent the symptoms of a stuffy, runny or itchy nose (rhinitis).
Use one spray into each nostril two to four times daily.
If you are using it for hay fever, start using it 2-3 weeks before the hay fever season begins and use it regularly, even if your symptoms are well controlled.
At a glance
Cromolyn sodium nasal spray is an anti-allergy medicine for nasal symptoms from allergies.
It helps prevent symptoms like sneezing, blocked or runny nose, and itchy nose.
This spray does not contain steroids.
Common side effects include nasal stinging, headache, and sneezing.
It can take several days to start working, and up to 2-4 weeks for full benefit.
Use it regularly, even before allergy season for best results.
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Clinical author's note Michael Stewart 31/01/2018: Cromolyn sodium is known as sodium cromoglicate in the United Kingdom. There are no nasal preparations containing sodium cromoglicate currently available in the UK. This Medicine Leaflet is based on medicines information available in the UK and USA at the time of writing. Please also refer to the manufacturer's information supplied with your medicine.
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Overview
Type of medicine | An anti-allergy medicine |
Used for | Nasal symptoms caused by allergies (in adults and in children aged over 2 years) |
Also called | Nasalcrom®; sodium cromoglicate (in UK) |
Available as | Nasal spray |
What is cromolyn sodium nasal spray used for?
Back to contentsCromolyn sodium nasal spray is used to prevent and treat symptoms of allergic rhinitis (hay fever).
This is a condition where the inside of your nose becomes inflamed and irritated, causing symptoms include sneezing, a blocked or runny nose, and an itchy nose.
It is commonly caused by allergies to substances such as pollen and animal fur.
Cromolyn sodium nasal spray is available on prescription, or you can buy it over-the-counter at a pharmacy.
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How does cromolyn sodium work?
Back to contentsCromolyn sodium works by preventing the release of histamine and other inflammatory substances, helping to reduce allergic reactions and inflammation.
Histamine is normally released by the immune system when the body comes into contact with an allergen, such as pollen, dust, or pet dander.
Side effects of cromolyn sodium
Back to contentsCommon side effects of cromolyn sodium are:
Nasal stinging or burning.
Headache.
Sneezing.
A full list of side effects can be found in the manufacturer's leaflet.
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Before using cromolyn sodium nasal spray
Back to contentsTo make sure this is the right treatment for you, before you start using sodium cromoglicate nasal spray it is important that your doctor or pharmacist knows:
If you have ever had an allergic reaction to a medicine.
If you are pregnant, trying for a baby or breastfeeding. This is because while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
How to use cromolyn sodium nasal spray
Back to contentsRead the manufacturer's instructions to make sure you know how to work the spray.
Remove the protective cap. (Before you use the spray for the first time, activate the spray a few times until you can see a fine mist in the air.)
Blow your nose gently to clear it.
Close one nostril by placing a finger against one side of your nose. Then, using your other hand, put one finger on each side of the nozzle of the bottle and insert the nozzle into your open nostril. Try to keep the bottle upright as you do this.
Breathe in through your nose as you press down on the nozzle to activate the spray. Then remove the nozzle from your nostril and breathe out through your mouth.
Use the spray in your other nostril by repeating the steps above.
Wipe the nozzle with a clean tissue and replace the cap. (If the nozzle becomes blocked, you can remove it from the bottle and rinse it under warm water.)
Getting the most from your treatment
Back to contentsRead the information leaflet that comes with the spray before you start using it. It explains how to use the spray correctly and lists possible side effects.
The usual dose is one spray into each nostril 2-4 times a day. Use the spray regularly, even if your symptoms improve. Cromolyn sodium works by preventing allergy symptoms, rather than treating symptoms once they start.
If you are using the spray for hay fever, you may be advised to start treatment 2-3 weeks before the pollen season begins, as it can take a few days to start working.
If you forget a dose, use it as soon as you remember unless it is nearly time for your next dose. Do not use two doses at the same time.
How to store cromolyn sodium nasal spray
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Frequently asked questions
Back to contentsHow long does cromolyn sodium nasal spray take to work?
Cromolyn sodium nasal spray does not work instantly. It can take several days of regular use before symptoms begin to improve, and up to 2-4 weeks for full benefit.
For hay fever, it is often recommended to start using the spray before allergy season begins.
Is cromolyn sodium a steroid nasal spray?
No. Cromolyn sodium is not a steroid. It belongs to a group of medicines called mast cell stabilisers, which help prevent the release of histamine and other chemicals involved in allergic reactions.
Can cromolyn sodium nasal spray be used every day?
Yes. Cromolyn sodium nasal spray is designed for regular daily use to help prevent allergy symptoms such as sneezing, itching, and a runny or blocked nose.
It works best when used consistently, even when symptoms are mild or well controlled.
Can cromolyn sodium nasal spray be used with other allergy medicines?
Cromolyn sodium nasal spray may be used alongside other allergy treatments such as antihistamines or steroid nasal sprays, depending on your symptoms and medical history.
However, you should check with a doctor or pharmacist before combining allergy medicines to avoid unwanted side effects or interactions.
Important information about all medicines
Back to contentsImportant information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the emergency room of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
MHRA - Reporting adverse reactions
Report suspected side effects to medicines, vaccines, e-cigarettes, medical device incidents, defective or falsified (fake) products to the Medicines and Healthcare products Regulatory Agency to ensure safe and effective use.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
What is the recommended dosage for cromolyn sodium nasal spray?
The usual dose is one spray into each nostril, 2-4 times a day. It's important to use the spray regularly, even if your symptoms improve, to get the most benefit.
How should I prepare the nasal spray for its first use?
Before you use the spray for the first time, you need to activate it. Remove the protective cap and then press down on the nozzle a few times until you can see a fine mist in the air. This ensures the spray is ready for use.
What should I do if the nozzle of my nasal spray gets blocked?
If the nozzle becomes blocked, you can remove it from the bottle. Once removed, rinse it under warm water to clear any obstruction. Remember to wipe it clean and replace the cap after use.
Can children use cromolyn sodium nasal spray?
Yes, cromolyn sodium nasal spray can be used by adults and children aged over 2 years for nasal symptoms caused by allergies.
What kind of symptoms does cromolyn sodium nasal spray help with?
This nasal spray is used to prevent and treat symptoms of allergic rhinitis, commonly known as hay fever. These symptoms include sneezing, a blocked or runny nose, and an itchy nose, which are often caused by allergies to things like pollen and animal fur.
Further reading and references
- Manufacturer's FDA Drug Label, Cromolyn sodium 5.2 mg spray; Bausch and Lomb Inc. DailyMed, National Institutes of Health, US National Library of Medicine. Last updated June 1, 2021.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewerView full bio

Dr Colin Tidy, MRCGP
General Practitioner, Medical Author
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 17 Jan 2027
18 Jan 2024 | Latest version

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