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Diethylstilbestrol tablets

Diethylstilbestrol can be taken by both men and women. As a guide the usual dose for men is 1-3 mg daily, and for women it is 10-20 mg daily. Follow your doctor's instructions carefully.

Side-effects of the treatment include feeling sick (nausea), swollen feet and ankles and an increased risk of blood clots. Impotence and breast enlargement can occur in men.


At a glance

  • Diethylstilbestrol is an oestrogen hormone treatment for certain cancers.

  • It can be used for prostate cancer in men and breast cancer in post-menopausal women.

  • Tell your doctor about heart, blood vessel, or liver problems before taking it.

  • Take tablets exactly as prescribed, usually daily, with or without food.

  • Common side-effects include feeling sick and swollen feet or ankles.

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About diethylstilbestrol

Type of medicine

An oestrogen

Used for

Prostate cancer in men; breast cancer in women

Available as

Tablets

Diethylstilbestrol is an oestrogen hormone treatment which helps to control the symptoms of some cancers.

It is sometimes used to treat prostate cancer, particularly if other therapies are not suitable. It is also occasionally used in women to treat breast cancer (providing you have been through the menopause).

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking diethylstilbestrol it is important that your doctor knows:

  • If you have a heart condition or any problems with your blood vessels.

  • If you have any problems with the way your liver works.

  • If it is for breast cancer and you have not been through the menopause. This is because diethylstilbestrol must not be taken by a woman who could become pregnant.

  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

  • If you have ever had an allergic reaction to a medicine.

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  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about diethylstilbestrol, and will also provide you with a full list of the side-effects which you could experience from taking it.

  • Take diethylstilbestrol exactly as your doctor tells you to. Your doctor or pharmacist will tell you how many tablets to take a day, and these directions will also be printed on the label of the pack of tablets to remind you about what you have been told. As a guide, it is usual for men to take 1-3 mg daily, and for women to take 10-20 mg daily.

  • You can take the tablets either with or without food. Try to take your doses at the same time of day each day, as this will help you to remember to take your doses regularly.

  • If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, leave out the forgotten dose from the previous day and take the dose that is due as normal. Do not take two doses at the same time to make up for a missed dose.

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.

  • If you are having an operation or any dental treatment, tell the person carrying out the treatment that you are taking diethylstilbestrol.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with diethylstilbestrol. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Diethylstilbestrol side-effects

What can I do if I experience this?

Feeling sick (nausea)

Stick to simple foods - avoid rich or spicy meals. It may help to take your tablets after a meal

Swollen feet and ankles

Put your feet up whenever possible. Let your doctor know if this becomes troublesome

An increased risk of blood clots, impotence, breast enlargement (in men), bone pain (in women), withdrawal bleeding (in women), yellowing of the whites of your eyes or skin (jaundice)

Your doctor will discuss these with you before you start treatment

If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.

  • Keep all medicines out of the reach and sight of children.

  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.

If you buy any medicines, check with a pharmacist that they are suitable to take with your other medicines.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Report side effects to a medicine or vaccine

If you experience side effects, you can report them online through the Yellow Card website.

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Unsure about mixing medicines?

Check for possible interactions between medicines, supplements and foods before taking them together.

Frequently asked questions

Can diethylstilbestrol be used for other types of cancer besides prostate and breast cancer?

The article states that diethylstilbestrol is sometimes used to treat prostate cancer, particularly if other therapies are not suitable, and occasionally in women to treat breast cancer (post-menopause). It does not mention its use for other types of cancer.

What should I do if I forget to take my diethylstilbestrol dose?

If you forget a dose, take it as soon as you remember. If you don't remember until the next day, skip the missed dose from the previous day and take your scheduled dose as normal. Do not take two doses at the same time to compensate for a forgotten dose.

Why is it important for my doctor to know about my heart condition or blood vessel problems before I start diethylstilbestrol?

Some medicines are not suitable for people with certain conditions, or may require extra care. Having a heart condition or problems with your blood vessels is one of the important details your doctor needs to know to ensure diethylstilbestrol is safe and appropriate for you.

What is the typical dosage of diethylstilbestrol for men and women?

As a general guide, men typically take 1-3 mg daily, while women usually take 10-20 mg daily. Your doctor or pharmacist will provide specific instructions tailored to your treatment.

Can I take other medicines, including over-the-counter or herbal remedies, while on diethylstilbestrol?

It is important to inform your doctor about all other medicines you are taking, including those available without a prescription, as well as herbal and complementary medicines. This allows your doctor to check for any potential interactions.

How should I store my diethylstilbestrol tablets?

You should keep diethylstilbestrol out of the reach and sight of children. Store the medicine in a cool, dry place, away from direct heat and light.

Further reading and references

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About the authorView full bio

Author image

Michael Stewart, MRPharmS

Medicine Leaflet Review Manager – Contractor, Pharmacist

BPharm (Hons), MRPharmS

Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.

About the reviewer

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Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

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