Epinastine eye drops for hay fever
Relestat
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 27 Oct 2023
Meets Patient’s editorial guidelines
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Epinastine drops relieve eye irritation associated with allergies like hay fever.
Use one drop twice a day, in the morning and the evening
You should not wear soft contact lenses whilst being treated with epinastine eye drops.
At a glance
Epinastine eye drops relieve eye irritation from seasonal allergies like hay fever.
They work by blocking histamine, a chemical causing allergy symptoms.
Common side effects include blurred vision, stinging, or burning.
Do not use for more than 8 weeks unless your doctor advises.
Do not use if you wear soft contact lenses, are pregnant, or for children under 12.
See your doctor if symptoms do not improve within a week or get worse.
In this article:
Video picks for Allergy medicines
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About epinastine eye drops
Type of medicine | Antihistamine eye preparation |
Used for | Eye irritation associated with seasonal allergic conjunctivitis |
Also called | Relestat® |
Available as | Eye drops |
What are epinastine eye drops used for?
Back to contentsEpinastine eye drops are used to relieve eye symptoms (allergic conjunctivitis) caused by seasonal allergies such as hay fever.
Symptoms include red, itchy, watery, and irritated eyes, and often occur during the same season each year, particularly in spring and summer.
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How do epinastine eye drops work?
Back to contentsEpinastine eye drops work by blocking the effects of histamine, a chemical released during an allergic reaction.
When your eyes come into contact with allergens such as pollen, the body releases histamine, which can cause red, itchy, watery, and irritated eyes.
By blocking histamine on the surface of the eyes, epinastine helps reduce inflammation and relieve allergy symptoms.
Side effects of epinastine eye drops
Back to contentsCommon side effects of epinastine eye drops are:
Blurred vision.
Stinging.
Burning sensation.
You will find a full list in the manufacturer's information leaflet supplied with the drops.
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How to manage epinastine side effects
Back to contentsSpeak with your doctor if any of the following continue or become troublesome.
Common epinastine side effects (these affect fewer than 1 in 10 people) | What can I do if I experience this? |
Blurred vision, eye discomfort (such as burning or stinging) | These usually disappear within a few minutes of using the drops. Do not drive and do not use tools or machines unless your vision is clear |
If you experience any other symptoms which you think may be due to the drops, speak with your doctor or pharmacist for further advice.
Who should not use epinastine eye drops?
Back to contentsTo make sure this is the right treatment for you, before you start using the eye drops it is important that your doctor knows:
If you wear soft contact lenses.
If you are pregnant or breastfeeding. Although epinastine is not known to be harmful to babies, it is still important that you tell your doctor if you are expecting or breastfeeding a baby.
If the drops are for a child. Epinastine drops are not recommended for a child under 12 years of age.
If you have ever had an allergic reaction to an antihistamine or to any eye drops.
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
How to use epinastine eye drops
Back to contentsWash your hands well before you use the drops.
Open the bottle.
Tilt your head back a little and pull the lower lid of your eye downwards to form a pocket.
Hold the bottle upside down near to your eye. Try not to touch your eye as you do this.
Gently squeeze the bottle to release one drop into your eye.
Close your eye for a minute or two, and press gently on the side of your nose where the corner of your eye meets your nose. This helps to stop the drop from draining away and keeps it in your eye.
Repeat the process in your other eye if you have been told to use the drops in both eyes.
Put the cap back on the bottle.
Getting the most from your treatment
Back to contentsRead the leaflet supplied with your eye drops for more information and possible side effects.
Use epinastine eye drops twice daily, usually once in the morning and once in the evening. Do not use them for longer than 8 weeks.
Avoid touching the dropper tip with your eye, fingers, or other surfaces to help prevent infection.
Your vision may be blurred for a short time after using the drops. Wait until your vision is clear before driving or using machinery.
Speak to your doctor if your symptoms do not improve within a week or if they get worse.
If you use other eye drops, wait at least 5 minutes between each one.
Do not wear soft contact lenses while using epinastine eye drops unless your doctor advises otherwise.
How to store epinastine eye drops
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Eye drops only keep for four weeks once the bottle has been opened, so do not use the drops if the bottle has been open for longer than this. This will help to prevent eye infections.
Frequently asked questions
Back to contentsHow long do epinastine eye drops take to work?
Epinastine eye drops usually start relieving allergy symptoms within a few minutes, although full relief may take longer in some people.
How long can you use epinastine eye drops for?
Epinastine eye drops are usually used during allergy season and should not normally be used for longer than 8 weeks unless advised by a doctor.
Can I wear contact lenses while using epinastine eye drops?
Soft contact lenses should not usually be worn while using epinastine eye drops because the preservative in the drops can affect the lenses.
What should I do if epinastine eye drops are not working?
If your symptoms do not improve within a week of using epinastine eye drops, or if they get worse, speak to your doctor or pharmacist for advice.
Can I use epinastine eye drops with other eye drops?
Yes, you can use epinastine eye drops with other eye drops but leave at least 5-10 minutes between different eye drops to allow each medicine to work properly.
Important information about all medicines
Back to contentsImportant information about all medicines
If you buy any medicines check with a pharmacist that they are safe to use with your other medicines.
Never use more than the prescribed dose.
If you suspect that someone has swallowed some of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are using.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
What are the active ingredients in epinastine eye drops?
The article mentions epinastine is an antihistamine eye preparation, but it does not specify any other active or inactive ingredients. You can find a full list in the manufacturer's information leaflet supplied with the drops.
How often should I use epinastine eye drops?
Epinastine eye drops should be used twice daily, typically once in the morning and once in the evening.
Can children use epinastine eye drops for allergies?
Epinastine eye drops are not recommended for children under 12 years of age.
What should I do if I accidentally touch my eye with the dropper tip?
It's important to avoid touching the dropper tip with your eye, fingers, or any other surfaces to help prevent infection. If it happens, you should still put the cap back on the bottle and continue to store them properly. If you suspect an infection or experience irritation, you should speak to your doctor or pharmacist.
Is it safe to use epinastine eye drops if I am pregnant or breastfeeding?
If you are pregnant or breastfeeding, it is important to tell your doctor before using epinastine eye drops. Although epinastine is not known to be harmful to babies, your doctor needs to be aware of your situation.
Further reading and references
- Manufacturer's PIL, Relestat® 0.5 mg/ml eye drops solution; Abbvie Ltd, The electronic Medicines Compendium. Dated February 2022.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewerView full bio

Dr Colin Tidy, MRCGP
General Practitioner, Medical Author
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 26 Oct 2026
27 Oct 2023 | Latest version

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