Fluticasone nasal preparations
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 24 Apr 2023
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Fluticasone relieves symptoms of rhinitis such as a stuffy, runny or itchy nose.
It may take a few days of treatment before you feel the full effect.
If you are using it for hay fever, start using it 2-3 weeks before the hay fever season begins and use it regularly.
The most common side effects of fluticasone are dryness and irritation of the nose and throat.
At a glance
Fluticasone is a steroid medicine used to treat nasal allergies and nasal polyps.
It reduces inflammation and swelling in the nose, easing congestion, itching, and sneezing.
It is available as a nasal spray or nose drops.
Common side effects include dryness and irritation in the nose and throat.
If you buy it without a prescription, see a doctor if symptoms don't improve after 7 days.
Use it regularly for best results, even once symptoms are controlled.
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Overview
Type of medicine | Corticosteroid |
Used for | The spray is used for nasal allergies; the drops are used for nasal polyps |
Also called | Avamys® (fluticasone furoate); Flixonase®; Nasofan®; Pirinase® Hayfever (fluticasone propionate) |
Available as | Nasal spray and nose drops |
What is fluticasone used for?
Back to contentsFluticasone is a type of steroid (corticosteroid) used to prevent, or ease, rhinitis. This is a condition where the inside of your nose becomes inflamed and irritated. It is commonly caused by allergies, such as hay fever.
How does fluticasone work?
Fluticasone works by reducing inflammation and swelling in the nose, helping to relieve congestion, itching, sneezing, irritation, and discomfort of nasal allergies.
What is fluticasone available as?
Fluticasone is available on prescription as a nasal spray or nasal drops. There are several different brands available. You can also buy smaller packs of some brands without a prescription at pharmacies.
The Dymista® brand of fluticasone spray also contains a medicine called azelastine. Azelastine is an antihistamine. Antihistamines help to ease the symptoms of rhinitis too.
Fluticasone nose drops (brand Flixonase® Nasule) are used for nasal polyps. Polyps are small growths inside the nose that can cause symptoms similar to allergic rhinitis.
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Side effects of fluticasone
Back to contentsCommon side effects of fluticasone include:
Dryness and irritation of the nose and throat.
Unusual tastes and smells.
Blocked or congested nose.
Runny nose.
Itchy nose.
Headache.
You will find a full list in the manufacturer's information leaflet inside your pack.
How to manage fluticasone side effects
Back to contentsThe unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common side effects of fluticasone | What can I do if I experience this? |
Dryness and irritation of the nose and throat, mild nosebleeds, unusual tastes and smells | If any of these become troublesome, speak with a pharmacist or doctor |
Headache | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, speak with your doctor |
If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.
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Who should not use fluticasone
Back to contentsSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using fluticasone, let your doctor or pharmacist know:
If you have an infection in your nose.
If you have recently had any surgery on your nose.
If you have tuberculosis (TB).
If it is intended for a child. (Fluticasone is suitable for use by children, but only if it has been prescribed by a doctor.)
If you are pregnant or breastfeeding.
If you are taking or using other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine.
How to use fluticasone
Back to contentsHow to use fluticasone nasal spray
Read the manufacturer's instructions to make sure you know how to work the spray. Some sprays have a button to push; others work by pushing down on a collar around the bottle.
Shake the bottle well and remove the cap. (Before you use the spray for the first time, activate the spray a few times until you can see a fine mist in the air - this only needs to be done when you first start using a new bottle.)
Blow your nose gently to clear it.
Close one nostril by placing a finger against one side of your nose. Tilt your head forward slightly and insert the nozzle of the spray into the other nostril. Try to keep the bottle upright as you do this.
Breathe in through your nose as you activate the spray. Then remove the nozzle from your nostril and breathe out through your mouth. Repeat if you are using two sprays for each dose.
Repeat the step above in your other nostril.
Wipe the nozzle with a clean tissue and replace the cap.
How to use fluticasone nose drops
Blow your nose gently to clear it.
Remove one of the containers from the strip in the foil pack. Flick or shake the container to make sure the contents are well mixed. Hold the container so that the liquid is in the bottom and then twist the top tab to remove it.
Lie on a bed with your head hanging backwards over an edge. An alternative is to kneel or bend forwards with your head down. (Do not stand with your head just tipped backwards, as the drops will not reach all the surfaces inside your nose if you do this.)
Squeeze the container to release half of the solution into one nostril, and the rest into your other nostril (this will mean putting about six drops into each nostril).
Stay lying or bending down for two minutes after putting in the drops before getting up. This is so that the liquid stays for a while in your nose and does not immediately run out of your nose or down the back of your throat.
Getting the most from your treatment
Back to contentsRead the manufacturer's printed information leaflet from inside the pack for a step-by-step guide of how to use the spray/drops, and a full list of the side effects.
Try to remember to use fluticasone regularly, even if your symptoms are controlled.
If you forget a dose at your usual time, take it as soon as you remember unless your next dose is due. If your next dose is due then have the dose which is due and leave out the forgotten one. Do not 'double up' to make up for a missed dose.
If you are using fluticasone nasal spray
Use the spray in both nostrils.
Most adults use 2 sprays in each nostril once daily (e.g. Flixonase®, Nasofan®, Avamys®).
For Dymista®, use 1 spray in each nostril twice daily.
Check the label carefully to make sure you are using the correct dose for your brand.
Use it at the same time(s) each day.
Once symptoms improve, you may be able to reduce to 1 spray in each nostril once daily (if the label says this is suitable).
Keep using it regularly, even when symptoms are controlled.
If bought without seeing a doctor and there is no improvement after 7 days, book an appointment with your GP.
Do not use it more often or longer than recommended, as this may increase side effects.
Fluticasone can usually be used for up to 3 months, or longer if prescribed by a doctor.
For hay fever, start using it 2–3 weeks before the season begins for best results.
If you are using fluticasone nose drops
Use the drops once or twice daily as recommended by your doctor.
If your symptoms have not improved after 4-6 weeks of using the drops, contact your doctor for further advice.
How to store fluticasone
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Flixonase Nasules® only keep for four weeks once the foil wrapper has been opened. Always keep unused Nasules® in the foil and dispose of any which are unused after this time.
Check the label for how long you can use fluticasone spray once it has been opened. After this time, get a fresh supply.
Important information about all medicines
Back to contentsImportant information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.
Frequently asked questions
Back to contentsCan I use fluticasone during pregnancy?
Fluticasone can be used during pregnancy, with both nasal sprays and drops generally considered safe because very little of the medicine enters the bloodstream.
Can I drink alcohol while using fluticasone?
Yes, you can usually drink alcohol while using fluticasone. There are no known direct interactions between alcohol and fluticasone inhalers or nasal sprays.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
Can fluticasone be used by children?
Yes, fluticasone is suitable for use by children, but it must be prescribed by a doctor. It should not be given to a child without a doctor's consultation.
What should I do if my symptoms don’t improve after using the nasal spray for a week?
If you bought the fluticasone nasal spray without seeing a doctor and your symptoms haven't improved after 7 days, you should book an appointment with your GP.
When should I expect to see an improvement in my symptoms when using fluticasone nose drops?
If your symptoms have not improved after 4-6 weeks of using fluticasone nose drops, you should contact your doctor for further advice.
How long can I use fluticasone nasal spray for?
Fluticasone nasal spray can usually be used for up to 3 months. If a doctor has prescribed it, you might be able to use it for longer. It's important not to use it more often or for longer than recommended without medical advice, as this could increase side effects.
Why is Dymista® a combination product and how does it differ from other fluticasone sprays?
The Dymista® brand of fluticasone spray contains an additional medicine called azelastine, which is an antihistamine. Antihistamines also help to ease rhinitis symptoms, offering a combined effect with fluticasone's corticosteroid action. This makes it different from other fluticasone sprays that only contain fluticasone.
Further reading and references
- Manufacturer's PIL, Avamys® 27.5 micrograms nasal spray suspension; GlaxoSmithKline UK, The electronic Medicines Compendium. Dated February 2022.
- Manufacturer's PIL, Flixonase® Aqueous Nasal Spray; GlaxoSmithKline UK Ltd, The electronic Medicines Compendium. Dated August 2020.
- Manufacturer's PIL, Flixonase® Nasule Drops; Allen and Hanburys Ltd, The electronic Medicines Compendium. Dated August 2020.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewerView full bio

Dr Colin Tidy, MRCGP
General Practitioner, Medical Author
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 22 Oct 2027
24 Apr 2023 | Latest version

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