Gentamicin ear drops
Peer reviewed by Dr Colin Tidy, MRCGPLast updated by Michael Stewart, MRPharmSLast updated 7 Nov 2022
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Gentamicin drops are used to treat ear infections. Follow carefully the instructions you have been given for using the drops.
Unless you have been told otherwise, use two or three drops three or four times a day, and also at night.
Throw the bottle away after your treatment has finished, even if there is some liquid left.
The most common side effects of gentamicin are mild irritation, itching or stinging.
At a glance
Gentamicin ear drops treat bacterial ear infections.
They kill germs that cause infection and can also reduce inflammation if combined with hydrocortisone.
Common side effects include mild irritation, itching, or stinging.
Do not use these drops if you have a burst eardrum or myasthenia gravis without consulting your doctor.
Store drops in a cool, dry place and discard any opened bottles after four weeks.
Symptoms should improve significantly within seven days of use.
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Video picks for Infection treatment medicine
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About gentamicin ear drops
Type of medicine | Anti-infective ear drop |
Used for | Treatment of ear infections in adults and children |
Available as | Drops (which can be prescribed for use in eyes or ears) |
What are gentamicin ear drops used for?
Back to contentsGentamicin ear drops are used to treat bacterial ear infections. The drops kill germs (bacteria) which are the cause of infection.
If the ear is swollen as well as infected (as in otitis externa, for example), your doctor may prescribe gentamicin ear drops which also contain hydrocortisone. These drops will reduce the inflammation as well as treat the infection.
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Side effect of gentamicin ear drops
Back to contentsCommon side effects of gentamicin ear drops are:
Mild irritation.
Itching.
Stinging.
A full list of the side effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine.
Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Gentamicin ear drop side effects | What can I do if I experience this? |
Mild irritation, itching, or stinging | If this continues or becomes severe, speak with your doctor |
If you experience any other symptoms which you think may be due to the drops, speak with your doctor or pharmacist for further advice.
Who should not use gentamicin ear drops?
Back to contentsSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. Before you (or your child) start using gentamicin drops, it is important that your doctor knows:
If you have a burst (perforated) eardrum.
If you are pregnant or breastfeeding.
If you have ever had an allergic reaction to gentamicin or to any other antibiotic, or to any other ear drops.
If you have a condition called myasthenia gravis. This is a condition which causes muscle weakness.
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
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How to use gentamicin ear drops
Back to contentsAlways read the leaflet in the pack before starting lymecycline. It explains how to take it and lists possible side effects.
Wash your hands before you begin.
Clean your ear gently with warm water and pat it dry.
Remove the cap from the bottle of ear drops.
Lie down, or tilt your head a little, so that the affected ear is facing upwards.
Gently pull your earlobe to straighten the ear canal.
Hold the container upside down near to the ear. Try not to touch the inside of your ear as you do this.
Apply enough pressure to the container to release two or three drops into your ear.
Keep your ear facing upwards for a few minutes to allow the solution to come into contact with the affected area.
Repeat the process in your other ear if you have been asked to use the drops in both ears.
Replace the cap on to the bottle of drops.
Getting the most from your treatment
Back to contentsTake lymecycline exactly as your doctor tells you to and always check the label for the correct dose. It is usually 3-4 times a day and at night.
Don’t miss doses - if you forget, apply the drops as soon as you remember.
Don’t use cotton buds or objects inside your ear as they can irritate or damage the skin. Wipe only the outer ear with a clean cloth or tissue if there’s any discharge.
You will be prescribed a short course of treatment (usually no more than 7-10 days). If you feel your infection is no better after this time, make another appointment to see your doctor for advice.
How to store gentamicin ear drops
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Throw away the bottle of ear drops after you have finished your course of treatment, even if there is some liquid left.
Do not keep opened bottles to use later, as ear drops must not be used if the bottle has been opened for longer than four weeks.
Important information about all medicines
Back to contentsImportant information about all medicines
If you suspect that someone has swallowed some of this medicine, contact the accident and emergency department of your local hospital for advice
If you buy any medicines check with a pharmacist that they are safe to use with your other medicines.
If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are using.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.
Frequently asked questions
Back to contentsHow long does it take for gentamicin ear drops to work?
Gentamicin ear drops usually start to ease symptoms within a few days. Most infections improve significantly within 7 days, as long as the drops are used exactly as prescribed.
What does gentamicin do to the middle ear?
Gentamicin works by killing bacteria that cause middle ear infections, helping reduce pain, swelling and discharge. It is used carefully, as high doses or prolonged use can affect the balance or hearing structures in the inner ear.
Are gentamicin ear drops safe to use during pregnancy?
Gentamicin ear drops are generally avoided in pregnancy, as aminoglycosides can pose a small risk to the baby if significant absorption occurs. A doctor will usually recommend a safer alternative unless the benefits clearly outweigh the risks.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
Can gentamicin ear drops be used for inner ear infections?
The article states that gentamicin works by killing bacteria that cause middle ear infections. It also mentions that high doses or prolonged use can affect the balance or hearing structures in the inner ear, implying careful use, but does not explicitly state its use for inner ear infections.
What should I do if I accidentally miss a dose of my gentamicin ear drops?
If you forget to apply the drops, you should do so as soon as you remember. It's important not to miss doses to ensure the treatment is effective.
Is it safe to use cotton buds to clean my ears when using gentamicin ear drops?
No, you should not use cotton buds or any other objects inside your ear, as they can irritate or damage the skin. If there is any discharge, you should only wipe the outer ear with a clean cloth or tissue.
How long can I keep an opened bottle of gentamicin ear drops?
You should not use ear drops if the bottle has been opened for longer than four weeks. After finishing your course of treatment, you should throw away the bottle, even if there is some liquid remaining.
What if my ear infection doesn't get better after using the drops for the prescribed time?
You will typically be prescribed a short course of treatment, usually no more than 7-10 days. If you feel your infection is not improving after this period, you should make another appointment to see your doctor for further advice.
Are there any specific situations when I should be extra careful about using gentamicin ear drops?
Extra care should be taken if you have a perforated eardrum, are pregnant or breastfeeding, have a history of allergic reactions to antibiotics or other ear drops, or have a condition called myasthenia gravis, which causes muscle weakness. Your doctor needs to be aware of these conditions.
Further reading and references
- Manufacturer's PIL, Gentamicin Eye/Ear Drops 0.3%; FDC International Ltd, The electronic Medicines Compendium. Dated October 2020.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewerView full bio

Dr Colin Tidy, MRCGP
General Practitioner, Medical Author
MBBS, MRCGP, MRCP (Paediatrics), DCH
Dr Colin Tidy is an NHS Doctor, based in Oxfordshire.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 6 May 2027
7 Nov 2022 | Latest version

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