Hydroxocobalamin injection Cobalin-H, Neo-Cytamen

Authored by Mr Michael Stewart, 13 Dec 2016

Patient is a certified member of
The Information Standard

Reviewed by:
Prof Cathy Jackson, 13 Dec 2016

Hydroxocobalamin is used to treat some types of anaemia.

It is given by injection into a muscle.

Treatment with hydroxocobalamin is usually lifelong.

Type of medicineVitamin B12 replacement
Used forAnaemia caused by lack of vitamin B12, and some rare eye conditions
Also calledCobalin-H®; Neo-Cytamen®
Available asInjection

The most common cause of vitamin B12 deficiency in the UK is a condition called pernicious anaemia. This is a condition where insufficient amounts of vitamin B12 are absorbed into your body from the food you eat. This can be because you are not able to absorb it properly, or because you have had surgery which has removed part of your digestive system. This type of anaemia is easily treated by having regular injections of hydroxocobalamin, which is a form of vitamin B12.

Hydroxocobalamin is also occasionally used for some rare eye conditions.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start having hydroxocobalamin injections it is important that your doctor knows:

  • If you are pregnant or breast-feeding. (Hydroxocobalamin is not known to be harmful to an unborn baby or while breast-feeding, but nevertheless you should let your doctor know about this.)
  • If you have ever had an allergic reaction to a medicine.
  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
  • Hydroxocobalamin will usually be given to you by your doctor or nurse. It will be given by injection into a muscle.
  • When you first start treatment, you will need to have an injection every 2-3 days. This is to top up the store of vitamin B12 in your body. After a few weeks, you will only need to have one injection every 2-3 months. Your doctor will tell you when to arrange an appointment for you to have these injections. If ever you miss an appointment, you should contact your doctor's surgery to make another appointment as soon as possible so that you receive your injections on time.
  • Before you start this treatment, ask to read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about treatment with hydroxocobalamin.
  • Try to keep your regular doctor's appointments so that your progress can be checked. You may need to have some blood tests from time to time, particularly at the beginning of your treatment. The tests will check that the treatment is working, and will also check on the amount of potassium in your blood, as this may drop a little initially.

Along with their useful effects, all medicines can cause unwanted side-effects although not everyone experiences them. The table below lists some of the most common ones associated with hydroxocobalamin injections. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve in the first few days after having the injection, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Hydroxocobalamin side-effectsWhat can I do if I experience this?
Feeling sick (nausea)Stick to simple meals - avoid rich or spicy food
HeadacheDrink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headache continues, speak with your doctor
Feeling dizzyIf this happens, do not drive and do not use tools or machines until you feel well again
High temperature (fever), rash, itching or pain where you were injectedLet your doctor or nurse know about these

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor, nurse or pharmacist.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

If you are having an operation or dental treatment tell the person carrying out the treatment which medicines you are taking.

If you buy any medicines, check with a pharmacist that they are suitable to take with your other medicines.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Further reading and references

  • Manufacturer's PIL, Hydroxocobalamin Injection BP 1 mg/ml; Concordia International (formerly AMCo/Amdipharm Mercury Company Limited), The electronic Medicines Compendium. Dated February 2015.

  • British National Formulary; 72nd Edition (Sep 2016) British Medical Association and Royal Pharmaceutical Society of Great Britain, London

Hi Everyone!This is my first ever posting so I'm super nervous. I have recently been diagnosed with pernicious anaemia, I have started my loading doses and have had 1 so far, I was wondering how many...

molly30314
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