Metronidazole gel and cream
Anabact, Metrogel, Rozex
Peer reviewed by Sid DajaniLast updated by Michael Stewart, MRPharmSLast updated 19 Jan 2025
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Unless you are told otherwise by your doctor, use the gel/cream twice a day after gently washing the affected area.
Keep out of strong sunlight and do not use sunbeds, as the treated areas of your skin may become more sensitive than usual.
If your skin becomes irritated or dry, reduce the number of times you apply the preparation for a few days until your skin recovers.
At a glance
Metronidazole gel and cream are antimicrobial skin preparations.
They are used to treat rosacea or to reduce unpleasant smells from infected wounds.
For rosacea, apply a thin layer twice daily, usually for weeks or months.
For wounds, it is usually applied once or twice daily after cleaning.
Metronidazole can make your skin more sensitive to sunlight.
Side-effects can include skin irritation and dryness.
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What are metronidazole gel and cream used for?
Type of medicine | An antimicrobial skin preparation |
Used for | Rosacea; infected skin ulcers and wounds |
Also called | Acea®; Anabact®; Metrosa®; Metrogel®; Rozex® |
Available as | Cream and gel |
You will have been prescribed metronidazole gel or cream to apply to your skin for one of two completely different reasons - you will either have rosacea on your face, or you will have an infected wound that has an unpleasant smell.
Most brands of metronidazole gels and creams can be used to treat a skin condition called rosacea (sometimes referred to as acne rosacea). Rosacea is a skin condition that affects parts of your face. Symptoms of rosacea include flushing, redness, and small lumpy red spots. Although it can look similar to acne, it is, however, a completely different condition. Treatment of rosacea with metronidazole can last from six weeks to several months.
Two of the brands of metronidazole gel (called Anabact® and Metrogel®) are used to reduce unpleasant odours from an infected wound, such as a skin ulcer. If you have been prescribed metronidazole gel for this reason, your treatment will last for as long as is needed to control your symptoms.
This document does not give information about metronidazole when it is taken by mouth for an infection, or when it is used for vaginosis. More information on these topics is available in separate medicine leaflets, respectively called Metronidazole for infection and Metronidazole vaginal gel for treating bacterial vaginosis.
Before using metronidazole
Back to contentsTo make sure that this is the right treatment for you, before you start using metronidazole gel it is important that your doctor or pharmacist knows:
If you are pregnant or breastfeeding - metronidazole cream and gel are not known to be harmful to babies, but it is still important that you tell your doctor about this.
If you have ever had an allergic reaction to a medicine, or to any skin preparation.
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How to use metronidazole gel and cream
Back to contentsBefore you start using metronidazole gel or cream, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the brand of metronidazole prescribed for you to use, and it will also provide you with a full list of side-effects which you could experience from using it.
Unless you have been told otherwise by your doctor, use the gel/cream twice daily if you are using it for rosacea. Use it in the morning and the evening, by applying a thin layer to the affected area and rubbing it in gently. Take care not to get any cream/gel into your eyes or your mouth or the inside of your nostrils, as it could cause irritation in these areas. If this does happen, wash it off with warm water as soon as you are able.
If you are using metronidazole gel for a skin ulcer or wound, you will probably be advised to apply it once or twice daily after the area has been cleaned. Usually, your doctor will arrange for this to be done for you by a nurse.
Getting the most from your treatment
Back to contentsTry to keep any regular appointments with your doctor. This is so your doctor can check on your progress.
Metronidazole can cause your skin to become more sensitive to sunlight than usual. Protect treated areas of skin from strong sunlight, and do not use sunbeds.
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Can metronidazole gel or cream cause problems?
Back to contentsAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with metronidazole skin gel and cream. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.
Metronidazole gel or cream side-effects (these affect fewer than 1 in 10 people) | What can I do if I experience this? |
Skin irritation, skin dryness | Apply less of the preparation, or use it less often until the irritation has settled |
If you experience any other symptoms which you think may be due to the metronidazole cream or gel, speak with your doctor or pharmacist for further advice.
How to store metronidazole gel and cream
Back to contentsKeep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Back to contentsImportant information about all medicines
If you are having an operation or dental treatment, please tell the person carrying out the treatment which medicines you are taking or using.
This preparation is for use on the skin only. If someone swallows some of it by accident, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
The medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Report side effects to a medicine or vaccine
If you experience side effects, you can report them online through the Yellow Card website.

Unsure about mixing medicines?
Check for possible interactions between medicines, supplements and foods before taking them together.
Frequently asked questions
Can I use metronidazole gel for acne?
No, metronidazole gel is not used for acne. Although the skin condition rosacea can look similar to acne, it is a completely different condition. Metronidazole gel is specifically prescribed for rosacea or for infected wounds, not for acne.
How should I apply metronidazole cream if I am using it for rosacea?
For rosacea, you should typically apply a thin layer of the gel or cream to the affected area of your face twice daily, usually in the morning and evening. Rub it in gently, taking care to avoid getting it into your eyes, mouth, or nostrils, as it can cause irritation. If accidental contact occurs, wash the area with warm water.
What should I do if my skin becomes irritated or dry from using metronidazole gel?
Skin irritation and dryness are common side-effects affecting fewer than 1 in 10 people. If you experience these, you can try applying less of the preparation or using it less often until the irritation settles. If the problem continues or becomes bothersome, speak with your doctor or pharmacist for advice.
Does metronidazole gel for wounds require special care during application?
If you are using metronidazole gel for a skin ulcer or wound, it will generally be applied once or twice daily after the area has been cleaned. Your doctor will usually arrange for a nurse to perform this application for you to ensure it's done correctly and hygienically.
Is it safe to use metronidazole cream or gel if I am pregnant or breastfeeding?
If you are pregnant or breastfeeding, it is important to inform your doctor or pharmacist. While metronidazole cream and gel are not known to be harmful to babies, your doctor needs to be aware of your situation before prescribing.
Further reading and references
- Manufacturer's PIL, Metrogel® 0.75 % gel; Galderma (UK) Ltd, The electronic Medicines Compendium. February 2022.
- Manufacturer's PIL, Rozex® 0.75 % Cream; Galderma (UK) Ltd, The electronic Medicines Compendium. Dated March 2022.
- Medicines Complete BNF 89th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Next review due: 19 Jan 2028
19 Jan 2025 | Latest version

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