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Naftidrofuryl capsules


Take naftidrofuryl capsules three times daily with meals. Swallow the capsule with a glass of water.

Side-effects of treatment are uncommon but can include feeling sick (nausea), diarrhoea, and a skin rash.

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About naftidrofuryl

Type of medicine

5HT2 receptor antagonist

Used for

Blood circulation problems (vascular disease)

Also called

Nafronyl oxalate (in US); Praxilene®

Available as


Poor blood flow can lead to a lack of oxygen in your body tissues. This causes symptoms such as pain and discomfort. So, for example, poor blood flow in your legs can cause pain and discomfort when you walk. Poor blood flow can also cause cold and painful hands and feet in disorders such as Raynaud's syndrome. Naftidrofuryl works by allowing your body to make better use of the oxygen in your blood.

Before taking naftidrofuryl

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking naftidrofuryl it is important that your doctor knows:

  • If you have ever had a problem with kidney stones.

  • If you are pregnant or breastfeeding.

  • If you have any problems with the way your liver works.

  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

  • If you have ever had an allergic reaction to a medicine.

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How to take naftidrofuryl

  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about naftidrofuryl, and will also provide you with a full list of side-effects which you could experience from taking it.

  • Take the capsules exactly as your doctor tells you to. It is usual to take one or two capsules three times daily with meals. Your doctor will tell you which is the right dose for you, and this information will also be printed on the label of the pack of capsules to remind you about what the doctor said to you.

  • You should swallow the capsules with plenty of water (at least one full glass). This is to help prevent unwanted side-effects (such as kidney stones) and to stop the capsules from becoming lodged in your throat and causing irritation. Do not open or chew the capsules.

  • If you forget to take a dose, don't worry, just remember to take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.

Getting the most from your treatment

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress and assess how naftidrofuryl is working for you.

  • If you are a smoker, you should try to stop. Smoking can narrow your blood vessels further and will make your condition worse. Your doctor or pharmacist can advise you about how to quit smoking.

  • Keep your home warm. The cold cuts down the blood supply to your skin even before you feel cold. If you go out in the cold, wrap up well in warm clothing, especially gloves and socks.

  • Regular exercise will help to improve your circulation. Your doctor can advise you on what type of exercise is suitable for you.

  • Take good care of your hands and feet. Examine your hands, legs and feet regularly for any signs of damage or infection. If you notice any changes, please see your doctor for advice.

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Can naftidrofuryl cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with naftidrofuryl. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Naftidrofuryl side-effects (these affect fewer than 1 in 100 people)

What can I do if I experience this?

Feeling sick (nausea), stomach ache

Stick to simple foods - avoid rich or spicy foods. Make sure you take the capsules during your meals or straight afterwards

Skin rash

If troublesome, speak with your doctor


Drink plenty of water to replace any lost fluids

On rare occasions, some people taking naftidrofuryl have developed a liver disorder. If you notice any yellowing of your skin or the whites of your eyes, speak with your doctor straightaway.

If you experience any other symptoms which you think may be due to the capsules, speak with your doctor or pharmacist for further advice.

How to store naftidrofuryl

  • Keep all medicines out of the reach and sight of children.

  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

Important information about all medicines

If you buy any medicines 'over the counter', check with a pharmacist that they are safe to take with your prescribed medicines.

If you are due to have an operation or dental treatment, please tell the person carrying out the treatment which medicines you are taking.

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Report side effects to a medicine or vaccine

If you experience side effects, you can report them online through the Yellow Card website.

Further reading and references

Article history

The information on this page is written and peer reviewed by qualified clinicians.

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