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Selegiline for Parkinson's disease


The usual dose is one tablet daily.

Keep your regular appointments with your doctor so your progress can be monitored.

As your symptoms improve and your body movements become easier, be careful not to overdo physical activities.

Do not stop taking this medicine without speaking with your doctor first - stopping suddenly can cause problems.

Continue reading below

About selegiline

Type of medicine

A monoamine-oxidase-B inhibitor

Used for

Parkinson's disease

Also called


Available as


The symptoms of Parkinson's disease - tremor, stiffness and slow movement - are due to there being less of a chemical called dopamine in your brain. Selegiline works by increasing the effect of dopamine in the brain, and this helps to ease these typical symptoms.

You may be prescribed selegiline as a treatment on its own, or alongside other medicines for Parkinson's disease which contain a medicine called levodopa. When it is prescribed with other medicines, selegiline helps to prevent some of the problems which can occur with these other treatments. These problems may be referred to as 'end-of-dose' fluctuations, or 'on-off' symptoms.

Before taking selegiline

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking selegiline it is important that your doctor or pharmacist knows:

  • If you are pregnant or breastfeeding.

  • If you have a stomach or duodenal ulcer.

  • If you have high blood pressure, an irregular heartbeat, or angina pain.

  • If you have had a mental health problem (in particular, psychosis).

  • If you have a problem with the way your liver works, or with the way your kidneys work.

  • If you have a rare inherited blood disorder called porphyria.

  • If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

  • If you have ever had an allergic reaction to a medicine.

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How to take selegiline

  • Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about selegiline and will provide you with a full list of the side-effects which you may experience from taking it.

  • Take selegiline exactly as your doctor tells you to. The usual dose is one tablet a day, in the morning. When you first start taking it your doctor is likely to suggest you start on the lower-strength (5 mg) tablet. You may then be prescribed the higher-strength (10 mg) tablet after a couple of weeks. You can take selegiline 5 mg and 10 mg tablets before or after food.

  • If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.

Getting the most from your treatment

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.

  • As your condition improves and your body movements become easier, be careful not to overdo physical activities. You should increase your activity gradually to allow your body to adjust to any changes in balance, circulation and co-ordination.

  • If you drink alcohol, ask your doctor for advice. Your doctor may recommend that you do not drink alcohol while you are on this medicine.

  • If you buy any medicines, check with a pharmacist that they are safe to take alongside this medicine. Selegiline should not be taken with strong painkillers and medicines containing sympathomimetics (present in some remedies for coughs and colds, and in decongestant nasal sprays and tablets).

  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking selegiline.

  • Stopping treatment suddenly can cause problems and your doctor will want you to reduce your dose gradually if this becomes necessary. Do not stop taking the medicine without speaking with your doctor first.

Continue reading below

Can selegiline cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with selegiline. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common

selegiline side-effects (these

affect more than 1 in 10 people)

What can I do if I experience this?

Sore mouth

Let your doctor know about this


selegiline side-effects


affect fewer than 1 in 10 people)

What can I do if I experience this?

Feeling sick (nausea), stomach upset

Stick to simple foods - avoid rich or spicy meals. Drink plenty of water

Headache, other aches and pains

Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the aches continue, let your doctor know

Feeling light-headed when getting up from a sitting or lying position

Getting up and moving more slowly should help. If this continues, speak with your doctor

Feeling tired, shaky or dizzy

Do not drive and do not use tools or machines until you feel better

Uncontrolled muscle movements

Let your doctor know about this

Sleeping problems, feeling confused or depressed, hallucinations, blocked nose, sore throat, sweating

If any of these become troublesome, speak with your doctor

Important: On rare occasions, medicines that affect the level of serotonin in the brain can cause it to go too high and cause problems. The risk is higher if you are taking more than one medicine with this effect. Seek medical attention if you develop any combination of the following:

  • Stiff muscles or 'jerky' movements.

  • Unusually fast heartbeat.

  • High temperature (fever), feeling sick (nausea) or being sick (vomiting), diarrhoea.

  • Feeling delirious or seeing visions (hallucinating).

If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice.

How to store selegiline

  • Keep all medicines out of the reach and sight of children.

  • Store in a cool, dry place, away from direct heat and light.

Important information about all medicines

Important information about all medicines

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Report side effects to a medicine or vaccine

If you experience side effects, you can report them online through the Yellow Card website.

Further reading and references

  • Manufacturer's PIL, Eldepryl® Tablets, Orion Pharma (UK) Limited, The electronic Medicines Compendium. Dated March 2021.
  • Medicines Complete BNF 87th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

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