Guajillo and Tomatillo Salsa
Peer reviewed by UK recipe editorsAuthored by UK recipe editorsOriginally published 17 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
This vibrant guajillo and tomatillo salsa is a versatile addition to any Mexican-inspired feast. By toasting dried guajillo and de árbol chillies, you unlock a deep, smoky complexity that perfectly balances the sharp, zesty brightness of fresh tomatillos and a hint of orange juice. It is a sophisticated condiment that offers a beautiful balance of heat and acidity, making it an essential staple for those who appreciate authentic flavours.
As a naturally vegan recipe, this heart-healthy sauce is ideal for drizzling over roasted vegetables, dipping crunchy tortilla chips, or topping your favourite tacos. It is incredibly simple to prepare yet provides a professional-tasting result that far surpasses any shop-bought alternative. Prepare a batch in advance to allow the flavours to meld before serving at your next gathering.
In this article:
Continue reading below
Ingredients for Guajillo and Tomatillo Salsa
3 dried large guajillo or New Mexico chillies (20g total), wiped clean, stemmed, and seeded
1 dried chilli de árbol (5g), wiped clean, stemmed, and seeded
230g fresh tomatillos, husked and rinsed
40g chopped white onion
1 large garlic clove, chopped
1 tablespoon fresh orange juice
How to make Guajillo and Tomatillo Salsa
Heat a dry heavy medium skillet (not nonstick) over medium heat until hot, then toast chillies briefly on all sides, pressing flat with tongs, until slightly softened, about 3 minutes.
Simmer tomatillos in water to cover in a small saucepan until tender, about 5 minutes. Transfer with a slotted spoon to a blender and add chillies, onion, garlic, orange juice, and 3/4 teaspoons salt. Blend until smooth (use caution when blending hot liquids). Transfer to a bowl and cool to room temperature.
Disclaimer
While every effort has been made to ensure the information is accurate and up to date, individual needs may vary and dietary requirements can differ based on personal health conditions. Always check food labels and allergen information before preparing or consuming any recipe. If you have specific health concerns, allergies, intolerances, or are following a medically prescribed diet, seek advice from your GP, pharmacist, or a registered dietitian before making significant changes to your diet or lifestyle.
Article history
The information on this page is peer reviewed by qualified clinicians.
17 Jan 2026 | Originally published
Authored by:
UK recipe editors
Peer reviewed by
UK recipe editors

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.