Can I take Allupurinol and Ramipril together?
Drug interaction guide
Originally published 24 Jan 2026
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Taking these two medicines together can increase the risk of a serious allergic reaction or a drop in white blood cell counts, which helps your body fight infections. It may also increase the risk of a sudden drop in blood pressure or kidney problems.
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Why this happens
Both medicines can affect the immune system and how the kidneys filter waste. When used together, they can cause the body to overreact (hypersensitivity) or slow down the production of blood cells. Additionally, allopurinol may slightly increase the levels of ramipril in the blood.
What you should do
You can take these together, but your doctor should monitor you closely, especially when starting the treatment or changing doses. Seek medical help immediately if you develop a skin rash, hives, swelling of the face or throat, or a fever. Your doctor may perform regular blood tests to check your kidney function and blood cell counts.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

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