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Can I take Amlodipine and Liptor together?

Drug interaction guide

Taking amlodipine and Lipitor (atorvastatin) together can increase the amount of atorvastatin in your blood. This may increase the risk of side effects, particularly muscle pain or weakness.

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Why this happens

Amlodipine can slow down the body's ability to break down atorvastatin in the liver. This leads to higher levels of the cholesterol medicine circulating in your system.

What you should do

It is generally safe to take these together, but your doctor may choose to limit your dose of Lipitor (atorvastatin) or monitor you more closely. If you experience unexplained muscle pain, tenderness, or weakness, contact your doctor immediately.

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Important precautions

Grapefruit consumption

Avoid drinking large amounts of grapefruit juice. It can significantly increase the levels of these medicines in your blood, making side effects much more likely.

Food and drink warnings

Grapefruit and grapefruit juice

Grapefruit can increase the level of these medicines in your blood, which may increase the risk of side effects. For Lipitor, avoid drinking large quantities (more than 1.2 litres daily), though it is safest to avoid it altogether. For amlodipine, avoid grapefruit juice as it can lower your blood pressure too much.

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Using other medicines?

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 24 Jan 2026 | Originally published
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