Can I take Amlodipine and Liptor together?
Drug interaction guide
Originally published 24 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking amlodipine and Lipitor (atorvastatin) together can increase the amount of atorvastatin in your blood. This may increase the risk of side effects, particularly muscle pain or weakness.
In this article:
Continue reading below
Why this happens
Amlodipine can slow down the body's ability to break down atorvastatin in the liver. This leads to higher levels of the cholesterol medicine circulating in your system.
What you should do
It is generally safe to take these together, but your doctor may choose to limit your dose of Lipitor (atorvastatin) or monitor you more closely. If you experience unexplained muscle pain, tenderness, or weakness, contact your doctor immediately.
Continue reading below
Important precautions
Grapefruit consumption
Avoid drinking large amounts of grapefruit juice. It can significantly increase the levels of these medicines in your blood, making side effects much more likely.
Food and drink warnings
Grapefruit and grapefruit juice
Grapefruit can increase the level of these medicines in your blood, which may increase the risk of side effects. For Lipitor, avoid drinking large quantities (more than 1.2 litres daily), though it is safest to avoid it altogether. For amlodipine, avoid grapefruit juice as it can lower your blood pressure too much.
Continue reading below
Using other medicines?
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Codeine and Morphine together?
Taking codeine and morphine together significantly increases the risk of serious side effects, including extreme sleepiness, dizziness, and dangerous breathing problems. Because both drugs are strong painkillers from the same family (opioids), they 'stack' on top of each other, which can lead to an accidental overdose.

Treatment and medication
Can I take Iron and Levothyroxine together?
Taking iron supplements at the same time as levothyroxine can significantly reduce the amount of thyroid hormone your body absorbs. This can lead to an underactive thyroid (hypothyroidism), causing symptoms like tiredness, weight gain, feeling cold, and dry skin.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.