Can I take Amytriptaline and Aspirin together?

Why this happens

Amitriptyline belongs to a group of medicines that can affect how your blood platelets work. Aspirin is a blood-thinner that also stops platelets from sticking together. When used together, their combined effect makes it harder for your blood to clot, increasing the risk of internal bleeding.

What you should do

Use this combination with caution. If you need to take them together, watch for signs of bleeding such as dark, tarry stools, coughing up blood, or severe stomach pain. If you notice these symptoms, contact your doctor immediately. Your doctor may suggest a different painkiller or a medicine to protect your stomach.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.