Can I take Apixaban and Naproxen together?

Why this happens

Apixaban is an anticoagulant (blood thinner) that prevents clots by blocking a specific clotting factor. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that also thins the blood by preventing platelets from sticking together. Additionally, naproxen can irritate the lining of the stomach. When used together, their blood-thinning effects add up, making it much harder for your body to stop any bleeding that starts.

What you should do

You should avoid taking naproxen while you are on apixaban unless your doctor has specifically told you to do so and is monitoring you closely. If you need pain relief, paracetamol is generally a safer alternative. If you have already taken both and notice any unusual bleeding, severe headache, or dark stools, seek medical attention immediately.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.