Can I take Atorvastatin and Omeprazole together?

Why this happens

Omeprazole can affect the way the body breaks down atorvastatin by interfering with certain enzymes in the liver (CYP3A4) and transport proteins. It also changes the acidity of the stomach, which can slightly alter how much of the statin is absorbed into the bloodstream.

What you should do

You can continue taking both medicines as prescribed. If you notice any new or unusual muscle pain, tenderness, or weakness, you should inform your doctor. It is often helpful to take your atorvastatin at the same time each day to maintain steady levels in your body.

Important precautions

Pregnancy

You must not take this medicine if you are pregnant or planning to become pregnant, as it can harm the developing baby. Use effective contraception while taking it.

Muscle pain or weakness

Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. In rare cases, this can lead to serious kidney problems.

Severe or persistent diarrhoea

Contact your doctor if you develop severe or watery diarrhoea that does not stop, as this medicine can increase the risk of a serious bowel infection called C. difficile.

Food and drink warnings

Grapefruit juice

Grapefruit juice can increase the level of atorvastatin in your blood, which may increase the risk of side effects like muscle pain. Avoid drinking large amounts (more than 1.2 litres a day), though a small glass is usually fine.

Alcohol

Drinking large amounts of alcohol while taking atorvastatin can increase the risk of liver problems. It is best to keep your intake within the recommended limits.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.