Can I take Bactrim and Venlafaxine dexcel together?

Why this happens

Venlafaxine increases serotonin levels in the brain. Some components of Bactrim (sulfamethoxazole/trimethoprim) can interfere with how the body processes other chemicals, potentially leading to an over-accumulation of serotonin. Additionally, both drugs can independently lower sodium levels or affect the electrical activity of the heart (QT prolongation).

What you should do

You should consult your doctor before taking these together. If your doctor confirms you need both, be alert for symptoms like shivering, sweating, confusion, rapid heartbeat, or severe muscle stiffness. Seek medical help immediately if you feel dizzy, faint, or experience palpitations.

Important precautions

Severe skin reactions

Stop taking this medicine immediately and seek urgent medical help if you develop a skin rash, peeling, or mouth sores. These can be signs of rare but life-threatening skin reactions (Stevens-Johnson syndrome).

Serotonin Syndrome

Seek immediate medical attention if you experience high fever, agitation, confusion, or muscle twitching. This medicine can cause a dangerous build-up of serotonin, especially if taken with certain other antidepressants or painkillers.

Blood disorders

Contact your doctor immediately if you develop an unexplained sore throat, fever, or unusual bruising. This medicine can cause a serious drop in white blood cells or platelets.

Food and drink warnings

Alcohol

You should avoid drinking alcohol while taking venlafaxine. Combining the two can increase drowsiness, dizziness, and impair your coordination and judgement.

Caffeine (Coffee, tea, energy drinks)

Venlafaxine can increase the levels of caffeine in your blood, and caffeine can also increase your blood pressure. This may lead to feeling jittery, anxious, or having a racing heart. Monitor your intake.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.