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Can I take Chaga and Lions mane together?

Drug interaction guide

There are no known negative interactions between Chaga and Lion's Mane mushrooms. In fact, they are frequently taken together in 'mushroom blends' because they work in different ways to support the body. Chaga is primarily used for its antioxidant properties and immune support, while Lion's Mane is used for cognitive health and nerve support.

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Why this happens

These two fungi have different active compounds (polysaccharides and triterpenes in Chaga; hericenones and erinacines in Lion's Mane) that do not interfere with each other's absorption or metabolism in the body. They do not compete for the same pathways in the liver.

What you should do

It is generally safe to take these together. However, because both may have a very mild effect on thinning the blood or lowering blood sugar, you should monitor how you feel if you are already taking medication for diabetes or blood thinners (like warfarin). Always start with a low dose to see how your body reacts.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 24 Jan 2026 | Originally published
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