Can I take Chaga and Shiitake together?
Drug interaction guide
Originally published 24 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Both chaga and shiitake mushrooms can thin the blood and lower blood sugar levels. Taking them together might increase the risk of bruising, bleeding, or your blood sugar dropping too low (hypoglycaemia).
In this article:
Continue reading below
Why this happens
Both mushrooms contain compounds that can slow down blood clotting (antiplatelet effects) and improve how the body handles insulin, leading to an additive effect when combined.
What you should do
It is generally safe to eat these as part of a normal diet. However, if you are taking concentrated supplements, monitor your blood sugar levels closely (if diabetic) and watch for signs of easy bruising or bleeding. Consult your doctor before combining these supplements if you are scheduled for surgery or are taking blood-thinning medications like warfarin.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Amitriptyline and Zopiclone together?
Taking amitriptyline and zopiclone together can make you feel extremely drowsy, dizzy, and confused. It significantly increases the risk of falling over, especially in the dark or when getting out of bed at night. It can also cause your breathing to become very slow or shallow, and may lead to severe coordination problems.

Treatment and medication
Can I take Warfarin and Amoxicillin together?
Taking amoxicillin while on warfarin can increase the risk of bleeding. You might notice that your blood takes longer to clot, or you may experience unusual bruising or nosebleeds.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
24 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.