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Can I take Collagen and Omeprazole together?

Drug interaction guide

Taking omeprazole might make your collagen supplement slightly less effective. You may not get the full benefit of the collagen for your skin, joints, or hair.

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Why this happens

Collagen is a protein that needs stomach acid to be broken down into smaller pieces (amino acids) so your body can absorb it. Omeprazole works by reducing the amount of acid your stomach produces. With less acid available, your body may find it harder to fully digest and absorb the collagen supplement.

What you should do

You can continue to take both, but try to take them at different times. It is usually best to take your omeprazole first thing in the morning on an empty stomach (as prescribed) and take your collagen supplement at a different time of day, such as with a meal later in the afternoon, to give your body the best chance of absorbing it.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 24 Jan 2026 | Originally published
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