Can I take Digoxin and Licorice together?

Why this happens

Licorice contains a substance called glycyrrhizic acid. This causes the kidneys to flush potassium out of the body. Digoxin is very sensitive to potassium levels; when potassium is low, digoxin binds more strongly to the heart muscle, leading to digoxin poisoning (toxicity).

What you should do

You should strictly avoid eating natural black licorice or taking licorice root supplements while taking digoxin. Check food labels for 'licorice extract' or 'glycyrrhizic acid'. Most 'licorice-flavoured' sweets in the UK use anise oil for flavouring and are safe, but you must confirm they do not contain real licorice extract. If you feel sick, have a blurred yellow-green tint to your vision, or feel your heart racing or skipping beats, contact a doctor immediately.

Important precautions

Low potassium (Hypokalaemia)

Licorice (especially natural black licorice) can cause your body to lose potassium. Low potassium levels significantly increase the risk of digoxin toxicity, which can cause serious heart rhythm problems. Avoid consuming large amounts of licorice while taking digoxin.

Food and drink warnings

Natural black licorice (Liquorice)

Avoid eating large amounts of natural black licorice. It can cause your body to lose potassium, which increases the risk of digoxin toxicity (serious side effects). This applies to the root extract, not most licorice-flavoured sweets.

High-fibre foods (e.g., wheat bran)

Eating very large amounts of fibre at the same time as taking your tablet can reduce the amount of digoxin absorbed by your body. Try to take your medicine at least 2 hours before or after eating high-fibre foods.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.